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- W3030468274 abstract "ObjectiveTo analyze the phenomenon of sleep benefit in Parkinson′s disease (PD) and its correlation factors.MethodsOne hundred PD patients in Department of Neurology, Qilu Hospital of Shandong University from February 2017 to November 2017 were included. They were recorded in detail the clinical information and clinical classification. Sleep conditions were assessed by Pittsburgh Sleep Quality Index, Parkinson Disease Sleep Scale, Epworth Sleepiness Disorder Scale and Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire. The general information, disease duration, medication, movement function, sleep condition and anxiety status were compared between sleep benefit group and without sleep benefit group. The correlation factors of sleep benefit was evaluated using unconditional Logistic regression analysis.ResultsFifty-one cases (51%) of sleep benefit were determined in our cohort of 100 PD patients. Sleep benefit group adminstered lower levodopa equivalent daily dose (LEDD, (354.77±279.64) mg/d) compared with patients without sleep benefit ((510.76±266.26) mg/d, t=-2.734, P=0.006), including levodopa ((289.04±228.73) mg/d vs(392.65±211.20)mg/d, t=-2.366, P=0.021) and dopamine agonist dose ((41.13±51.48)mg/d vs(68.01±57.10)mg/d, t=-1.950, P=0.054). Sleep benefit group had higher percentage of using dopamine agonist (23(45.1%) vs 35(71.4%), χ2=7.112, P=0.008) and longer duration of nocturnal sleep episode((6.51±1.31) h vs(5.89±1.29)h, t=2.412, P=0.018). In addition, sleep benefit had a higher prevalence in tremor-dominant subtype of PD (19/27(70.4%)vs 20/46(43.5%), χ2=4.855, P=0.025). Logistic regression indicated that sleep benefit had a positive correlation with duration of nocturnal sleep episode and tremor-dominant subtype, as well as a negative correlation with LEDD and dose of levodopa. LEDD and duration of nocturnal sleep episode were the independent factors of sleep benefit (OR=0.998, 95%CI 0.997-1.000, P<0.05; OR=1.407, 95%CI 1.004-1.972, P<0.05).ConclusionPD patients with sleep benefit administered low dose of dopamine and took long nocturnal sleep, which may relate to the relatively preserved dopamine storage function of dopaminergic neurons.Key words: Parkinson disease; Sleep; Levodopa; Dopamine agonists" @default.
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- W3030468274 date "2018-08-08" @default.
- W3030468274 modified "2023-09-28" @default.
- W3030468274 title "Sleep benefit and its correlation factors in Parkinson′s disease" @default.
- W3030468274 doi "https://doi.org/10.3760/cma.j.issn.1006-7876.2018.08.003" @default.
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