Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030477673> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3030477673 endingPage "356" @default.
- W3030477673 startingPage "352" @default.
- W3030477673 abstract "ObjectiveTo observe the levels of Th17 and associated cytokine IL-17 and Treg in peripheral blood in children with Henoch-Schonlein purpura nephritis(HSPN), and to explore the balance of regulation of Th17/Treg and the function of improvement of clinical symptoms in children with HSPN by using Huaiqihuang.MethodsThe objects were divided into 3 groups: healthy control group(n=11), Henoch-Schonlein purpura(HSP) group(n=10) and HSPN group(n=30). Healthy children were measured for the level of IL-17 by enzyme-linked immunosorbent assay(ELISA) and the circulating frequencies of Th17 and CD4+ CD25+ Treg cells by flow cytometry(FCM). HSP group and HSPN group were measured for the levels of IL-17, Th17 cells and Treg cells when illness had acute attack and had not used any drugs.Furthermore, HSPN group was measured for 24-hour urine proteins and urinary sediment red blood cells(RBCs). Patients in HSPN group with the pathological grading Ⅱ were divided into conventional therapy group(n=10) and Huaiqihuang group(n=10) randomly.Patients in HSPN group with the pathological grading Ⅲa were divided into Prednisone group(n=5) and Prednisone+ Huaiqihuang group(n=5) randomly.Conventional therapy group was treated with oral Fosinopril and Dipyridamole.Huaiqihuang group was treated with conventional therapy and oral Huaiqihuang particles.Prednisone group was treated with conventional therapy and oral Prednisone.Prednisone+ Huaiqihuang group was treated with conventional therapy, Prednisone and Huaiqihuang particles.After 2 months of treatments, the levels of IL-17, Th17 cells, Treg cells, 24-hour urine proteins and urinary sediment RBCs were mea-sured.ResultsThe circulating frequencies of Th17 cells and IL-17 in HSP group and HSPN group were higher than those in healthy control group(all P 0.05). Th17 cells, IL-17 levels and urinary sediment RBCs in conventional therapy group after treatment were lower than before, while Treg cells were higher than before, but there was no significant difference(all P>0.05). Twenty-four hour urine proteins were lower after treatment than before(P 0.05).ConclusionsTh17 cells and associated cytokine IL-17 levels increase in peripheral blood of children with HSPN, while Treg cells decrease in HSPN.Huaiqihuang can decrease Th17 cells and IL-17 level, and increase Treg cells.Furthermore, it can decrease hematuria and proteinuria.Key words: Henoch-Schonlein purpura nephritis; Th17; Treg; Huaiqihuang" @default.
- W3030477673 created "2020-06-05" @default.
- W3030477673 creator A5006242218 @default.
- W3030477673 creator A5013796261 @default.
- W3030477673 creator A5026330535 @default.
- W3030477673 creator A5067489320 @default.
- W3030477673 creator A5070973930 @default.
- W3030477673 creator A5085346129 @default.
- W3030477673 creator A5086605355 @default.
- W3030477673 date "2013-03-05" @default.
- W3030477673 modified "2023-09-27" @default.
- W3030477673 title "Balance of regulation of Th17/Treg in children with Henoch-Schönlein purpura nephritis using Huaiqihuang" @default.
- W3030477673 doi "https://doi.org/10.3760/cma.j.issn.2095-428x.2013.05.010" @default.
- W3030477673 hasPublicationYear "2013" @default.
- W3030477673 type Work @default.
- W3030477673 sameAs 3030477673 @default.
- W3030477673 citedByCount "0" @default.
- W3030477673 crossrefType "journal-article" @default.
- W3030477673 hasAuthorship W3030477673A5006242218 @default.
- W3030477673 hasAuthorship W3030477673A5013796261 @default.
- W3030477673 hasAuthorship W3030477673A5026330535 @default.
- W3030477673 hasAuthorship W3030477673A5067489320 @default.
- W3030477673 hasAuthorship W3030477673A5070973930 @default.
- W3030477673 hasAuthorship W3030477673A5085346129 @default.
- W3030477673 hasAuthorship W3030477673A5086605355 @default.
- W3030477673 hasConcept C126322002 @default.
- W3030477673 hasConcept C18903297 @default.
- W3030477673 hasConcept C203014093 @default.
- W3030477673 hasConcept C207886595 @default.
- W3030477673 hasConcept C2777058396 @default.
- W3030477673 hasConcept C2777121669 @default.
- W3030477673 hasConcept C2778720950 @default.
- W3030477673 hasConcept C71924100 @default.
- W3030477673 hasConcept C86803240 @default.
- W3030477673 hasConcept C90924648 @default.
- W3030477673 hasConceptScore W3030477673C126322002 @default.
- W3030477673 hasConceptScore W3030477673C18903297 @default.
- W3030477673 hasConceptScore W3030477673C203014093 @default.
- W3030477673 hasConceptScore W3030477673C207886595 @default.
- W3030477673 hasConceptScore W3030477673C2777058396 @default.
- W3030477673 hasConceptScore W3030477673C2777121669 @default.
- W3030477673 hasConceptScore W3030477673C2778720950 @default.
- W3030477673 hasConceptScore W3030477673C71924100 @default.
- W3030477673 hasConceptScore W3030477673C86803240 @default.
- W3030477673 hasConceptScore W3030477673C90924648 @default.
- W3030477673 hasIssue "5" @default.
- W3030477673 hasLocation W30304776731 @default.
- W3030477673 hasOpenAccess W3030477673 @default.
- W3030477673 hasPrimaryLocation W30304776731 @default.
- W3030477673 hasRelatedWork W2279625574 @default.
- W3030477673 hasRelatedWork W2356315527 @default.
- W3030477673 hasRelatedWork W2363389677 @default.
- W3030477673 hasRelatedWork W2366860064 @default.
- W3030477673 hasRelatedWork W2369665816 @default.
- W3030477673 hasRelatedWork W2381862256 @default.
- W3030477673 hasRelatedWork W2385197700 @default.
- W3030477673 hasRelatedWork W2389625560 @default.
- W3030477673 hasRelatedWork W2978097576 @default.
- W3030477673 hasRelatedWork W2997089571 @default.
- W3030477673 hasRelatedWork W2997753200 @default.
- W3030477673 hasRelatedWork W3019075582 @default.
- W3030477673 hasRelatedWork W3024161005 @default.
- W3030477673 hasRelatedWork W3027536770 @default.
- W3030477673 hasRelatedWork W3029302866 @default.
- W3030477673 hasRelatedWork W3029636982 @default.
- W3030477673 hasRelatedWork W3029761480 @default.
- W3030477673 hasRelatedWork W3029973330 @default.
- W3030477673 hasRelatedWork W3030679493 @default.
- W3030477673 hasRelatedWork W3111296451 @default.
- W3030477673 hasVolume "28" @default.
- W3030477673 isParatext "false" @default.
- W3030477673 isRetracted "false" @default.
- W3030477673 magId "3030477673" @default.
- W3030477673 workType "article" @default.