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- W3030481639 abstract "目的 研究大肠癌组织中生长抑素(SS)的表达与细胞周期调控因子--细胞周期素(cyclins)、细胞周期依赖性蛋白激酶(CDKs)表达的相关性,了解SS对大肠癌细胞增殖的具体调控机制,从而进一步完善大肠癌的发病机制,为激素依赖性大肠癌的内分泌联合基因治疗提供理论依据.方法随机选择79例大肠癌(结肠癌、直肠癌)患者的手术切除标本,用免疫组织化学方法中的SP法检测SS、cyclinD1、cyclinE、cyclinA、cyclinB1、cdc2、CDK2、CDK4的表达情况.结果CyclinE、CDK2在大肠癌组织SS高表达组的表达低于低表达组(P＜0.05).CyclinD1、cyclinA、cy-clinB1、cdc2、CDK4在大肠癌组织SS高、中、低表达组三组间相比较差异无统计学意义(P＞0.05).结论在大肠癌组织中,SS表达的水平越高,cyclinE、CDK2的阳性表达率越低,因此,SS对大肠癌细胞周期的调控可能是:SS抑制大肠癌细胞cyclinE、CDK2基因的表达,使cyclinE-CDK2复合物的水平降低,进而抑制细胞从G1期到S期的转化,使进入S期的细胞数减少,以诱导细胞周期阻滞,抑制细胞增殖。" @default.
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- W3030481639 date "2006-07-15" @default.
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- W3030481639 title "Investigation of the correlation between cyclins, CDKs and somatostatin in large intestine carcinoma" @default.
- W3030481639 doi "https://doi.org/10.3760/cma.j.issn.1673-4904.2006.20.007" @default.
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