Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030481650> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3030481650 endingPage "591" @default.
- W3030481650 startingPage "588" @default.
- W3030481650 abstract "Objective To investigate the expression of Wnt-5a gene in primary hepatocellular carcinoma (HCC) and to expose its role and clinical significance in the development of HCC.Methods Real time quantitative reverse transcription polymerase chain reaction (RT-PCR) was performed in 26 fresh HCC samples and the corresponding para-carcinoma tissues to detect mRNA expression of Wnt-5a gene.Wnt-5a protein was detected with immunohistochemical method in paraffin embedding tissues of 85 cases of HCCs and the corresponding para-carcinoma tissues,and 15 cases of hepatic cirrhosis.Results RT-PCR analysis showed that Wnt-5a mRNA (0.102 127 ±0.158 620) in the HCC tissues was more than that (0.020 106 ±0.022 075) in the para-carcinoma tissues (P＜0.05).The positive expression rate of Wnt-5a protein in HCC,para-carcinoma,and hepatic cirrhosis tissues were 21.2％ (18/85),81.26％ (69/85),and 86.7％ (13/15),respectively.The positive rate of Wnt-5a was significantly lower in the HCC than in the para-carcinoma and hepatic cirrhosis tissues (P ＜ 0.01).The expression of Wnt-5a was significantly associated with lower tumor node metastasis (TNM) stages and small alpha fetoproteins (AFP) content of blood serum (P ＜0.05).Conclusions The high expression of Wnt-5a mRNA was found in the gene transcription of HCC,while Wnt-5a protein was absent or low in HCC.It was suggested that the roles of Wnt-5a was interfered at the protein level rather than the transcriptional level in the HCC.Key words: Carcinoma, hepatocellular/genetics ; Proto-oncogenes ; Polymerase chain reaction; Immunohistochemistry" @default.
- W3030481650 created "2020-06-05" @default.
- W3030481650 creator A5002551693 @default.
- W3030481650 creator A5037870079 @default.
- W3030481650 creator A5046739156 @default.
- W3030481650 creator A5048502490 @default.
- W3030481650 creator A5061074781 @default.
- W3030481650 creator A5077051264 @default.
- W3030481650 date "2014-05-20" @default.
- W3030481650 modified "2023-09-23" @default.
- W3030481650 title "Expression and clinical significance of Wnt-5a gene in primary hepatocellular carcinomas" @default.
- W3030481650 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2014.05.004" @default.
- W3030481650 hasPublicationYear "2014" @default.
- W3030481650 type Work @default.
- W3030481650 sameAs 3030481650 @default.
- W3030481650 citedByCount "0" @default.
- W3030481650 crossrefType "journal-article" @default.
- W3030481650 hasAuthorship W3030481650A5002551693 @default.
- W3030481650 hasAuthorship W3030481650A5037870079 @default.
- W3030481650 hasAuthorship W3030481650A5046739156 @default.
- W3030481650 hasAuthorship W3030481650A5048502490 @default.
- W3030481650 hasAuthorship W3030481650A5061074781 @default.
- W3030481650 hasAuthorship W3030481650A5077051264 @default.
- W3030481650 hasConcept C104317684 @default.
- W3030481650 hasConcept C105580179 @default.
- W3030481650 hasConcept C121608353 @default.
- W3030481650 hasConcept C126322002 @default.
- W3030481650 hasConcept C137620995 @default.
- W3030481650 hasConcept C142724271 @default.
- W3030481650 hasConcept C150194340 @default.
- W3030481650 hasConcept C204232928 @default.
- W3030481650 hasConcept C2777214474 @default.
- W3030481650 hasConcept C2777546739 @default.
- W3030481650 hasConcept C2778019345 @default.
- W3030481650 hasConcept C2779013556 @default.
- W3030481650 hasConcept C2779314089 @default.
- W3030481650 hasConcept C4692481 @default.
- W3030481650 hasConcept C48023723 @default.
- W3030481650 hasConcept C502942594 @default.
- W3030481650 hasConcept C55493867 @default.
- W3030481650 hasConcept C71924100 @default.
- W3030481650 hasConcept C86803240 @default.
- W3030481650 hasConceptScore W3030481650C104317684 @default.
- W3030481650 hasConceptScore W3030481650C105580179 @default.
- W3030481650 hasConceptScore W3030481650C121608353 @default.
- W3030481650 hasConceptScore W3030481650C126322002 @default.
- W3030481650 hasConceptScore W3030481650C137620995 @default.
- W3030481650 hasConceptScore W3030481650C142724271 @default.
- W3030481650 hasConceptScore W3030481650C150194340 @default.
- W3030481650 hasConceptScore W3030481650C204232928 @default.
- W3030481650 hasConceptScore W3030481650C2777214474 @default.
- W3030481650 hasConceptScore W3030481650C2777546739 @default.
- W3030481650 hasConceptScore W3030481650C2778019345 @default.
- W3030481650 hasConceptScore W3030481650C2779013556 @default.
- W3030481650 hasConceptScore W3030481650C2779314089 @default.
- W3030481650 hasConceptScore W3030481650C4692481 @default.
- W3030481650 hasConceptScore W3030481650C48023723 @default.
- W3030481650 hasConceptScore W3030481650C502942594 @default.
- W3030481650 hasConceptScore W3030481650C55493867 @default.
- W3030481650 hasConceptScore W3030481650C71924100 @default.
- W3030481650 hasConceptScore W3030481650C86803240 @default.
- W3030481650 hasIssue "05" @default.
- W3030481650 hasLocation W30304816501 @default.
- W3030481650 hasOpenAccess W3030481650 @default.
- W3030481650 hasPrimaryLocation W30304816501 @default.
- W3030481650 hasRelatedWork W2104813699 @default.
- W3030481650 hasRelatedWork W2153854421 @default.
- W3030481650 hasRelatedWork W2286051369 @default.
- W3030481650 hasRelatedWork W2348131323 @default.
- W3030481650 hasRelatedWork W2353789721 @default.
- W3030481650 hasRelatedWork W2356780126 @default.
- W3030481650 hasRelatedWork W2359639658 @default.
- W3030481650 hasRelatedWork W2362237010 @default.
- W3030481650 hasRelatedWork W2365119592 @default.
- W3030481650 hasRelatedWork W2365224344 @default.
- W3030481650 hasRelatedWork W2370109898 @default.
- W3030481650 hasRelatedWork W2373878034 @default.
- W3030481650 hasRelatedWork W2381242974 @default.
- W3030481650 hasRelatedWork W2389035857 @default.
- W3030481650 hasRelatedWork W2391463974 @default.
- W3030481650 hasRelatedWork W3029286471 @default.
- W3030481650 hasRelatedWork W3029690183 @default.
- W3030481650 hasRelatedWork W3030299894 @default.
- W3030481650 hasRelatedWork W3031782249 @default.
- W3030481650 hasRelatedWork W2566644103 @default.
- W3030481650 hasVolume "16" @default.
- W3030481650 isParatext "false" @default.
- W3030481650 isRetracted "false" @default.
- W3030481650 magId "3030481650" @default.
- W3030481650 workType "article" @default.