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- W3030481898 abstract "核苷(酸)类似物广泛用于人类免疫缺陷病毒(human immunodeficiency virus，HIV)与乙型肝炎病毒(hepatitis B virus，HBV)感染的抗病毒治疗，该类药物大多经肾脏清除，部分有肾毒性，长期用药的肾脏安全性值得关注，对合并肾功能不全及其高风险患者尤应谨慎选择用药。丙酚替诺福韦(tenofovir alafenamide，TAF)的出现是核苷(酸)类似物近期较为重要的研究进展，其具备良好的肾脏安全性，是多个国际指南推荐的HIV、HBV抗病毒治疗一线用药；2018年7月以来TAF单药及含TAF的复方单片剂已在中国获批。现对常用核苷(酸)类似物，特别是国际研究中TAF的肾脏安全性数据进行阐述，为肾功能损伤HBV、HIV感染者的治疗提供参考。" @default.
- W3030481898 created "2020-06-05" @default.
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- W3030481898 date "2019-08-15" @default.
- W3030481898 modified "2023-09-23" @default.
- W3030481898 title "Value of tenofovir alafenamide in patients with hepatitis B virus or human immunodeficiency virus infection and comorbid renal impairment" @default.
- W3030481898 doi "https://doi.org/10.3760/cma.j.issn.1000-6680.2019.08.002" @default.
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