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- W3030482777 abstract "ObjectiveTo study the effect of Huayi decoction in the treatment of recurrent endometriosis, and its influence on Th1/Th2 balance.Methods92 patients with recurrent endometriosis were selected as the research subjects.According to the digital table method, the patients were randomly divided into the observation group and the control group, 46 cases in each group.The control group was given mifepristone, every time 12.5mg, 1 time/day, continuously treated for 3 months.The observation group was treated with Huayi decoction for 3 months.The serum carbohydrate antigen 125(CA125), interferon gamma(IFN-γ), interleukin 4(IL-4) were measured before and after treatment.ResultsAfter treatment, the effective rate of the control group was 78.3%, which was significantly lower than 91.3% of the observation group (χ2=5.16, P<0.05). Before and after treatment, the serum CA125 levels of the control group were (103.62±27.45)IU/mL, (55.21±19.23)IU/mL, respectively.Before and after treatment, the serum CA125 levels of the observation group were (106.85±22.74)IU/mL, (31.47±12.94)IU/mL, respectively.After treatment, the serum CA125 levels were significantly lower in the two groups(t=10.963, 14.206, all P<0.01), and the serum CA125 level in the observation group was significantly lower than that in the control group (t=5.038, P<0.05). The IL-4, IFN-γ, IL-4/IFN-γ of the control group before treatment were (22.61±6.72)pg/mL, (51.77±8.09)pg/mL and (0.41±0.11), respectively, which after treatment were (15.16±5.04)pg/mL, (60.39±9.14)pg/mL and (0.22±0.07), respectively.The IL-4, IFN-γ, IL-4/IFN-γ of the observation group before treatment were (23.01±6.71)pg/mL, (51.16±7.63)pg/mL and (0.42±0.15), respectively, which after treatment were (9.03±3.37)pg/mL, (69.91±8.24)pg/mL and (0.12±0.05), respectively.After treatment, the serum IL-4 levels of the two groups were significantly lower(t=6.0143, 8.770, all P<0.01), and the decrease of IL-4 level of the observation group was more significant (t=3.448, P<0.05). After treatment, the serum IFN-γ levels were significantly higher in the two groups (t=2.014, 2.998, all P<0.05), and the increase of IFN-γ level of the observation group was more significant (t=2.106, P<0.05). After treatment, the serum IL-4/IFN-γ of the two groups were significantly lower(t=5.182, 9.062, all P<0.01), and the IL-4/IFN-γ decreased more significantly in the observation group (t=5.824, P<0.05).ConclusionHuayi decoction can significantly improve the postoperative curative effect and improve the imbalance of Th1/Th2.Key words: Endometriosis; Recurrence; Drugs, chinese herbal; Huayi Tan" @default.
- W3030482777 created "2020-06-05" @default.
- W3030482777 creator A5034960303 @default.
- W3030482777 date "2018-04-15" @default.
- W3030482777 modified "2023-09-23" @default.
- W3030482777 title "Clinical effect of Huayi decoction in the treatment of recurrent endometriosis" @default.
- W3030482777 doi "https://doi.org/10.3760/cma.j.issn.1008-6706.2018.08.016" @default.
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