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- W3030483890 abstract "Objectives To investigate the sensitization to HLA antigens in long-term renal transplant recipients and analyze the relationship between sensitization and allograft function.Methods Among the 66 recipients surviving more than 3 years.46 patients had normal renal function and 20 had chronic allograft dysfunction.The serum soluble HLA-IgG antibodies were detected by using LAT ELISA kit.The specificity and type of antibodies were determined by using LAT software and relationship between sensitization and renal function and the pcxsttransplant duration analyzed.Results Mild sensitization.moderate sensitization and strong sensitization were found in 9 cases,0 and 2 in nornlal allograft function group,and 3,1 and 4 in chronic allograft dysfunction group,respectively.Eight cases were sensitized by HLA class Ⅱ antigen,3 cases by both class Ⅰ and Ⅱ.nobody was sensitized by class Ⅰ in normal allograft function group.In chronic allograft dysfunction group,one case was sensitized by class Ⅰ antigen,2 by class Ⅱ,5 by both class Ⅰ and Ⅱ.Sensitization rate in different posttransplant intervals had no significant difference.Conclusions Sensitization rate has no relevance to Posttransplant intervals.HLA class Ⅱ antigens take main responsibility for sensitization.Strong sensitization and sensitization by both dass Ⅰ and Ⅱ antigens at the same time are detrimental to the allograft damage.Key words: Kidney transplantation; Monitoring,immunologic; HLA antigens; Antibody formation" @default.
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- W3030483890 date "2000-05-20" @default.
- W3030483890 modified "2023-09-25" @default.
- W3030483890 title "Detection of sensitization to HLA antigens in long-term renal transplant recipients and its clinical implication" @default.
- W3030483890 doi "https://doi.org/10.3760/cma.j.issn.0254-1785.2000.03.002" @default.
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