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- W3030485056 abstract "目的观察亚慢性砷中毒大鼠血脂谱变化的特征并对其机理进行研究.方法采用亚慢性毒性实验方法,大鼠经口灌胃染毒,实验期为6周.实验结束后采血分离血清测甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),取部分肝脏左叶测一氧化氮(NO)、环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)并做光镜、电镜标本.结果①亚慢性砷中毒大鼠血清中TG、LDL-C含量下降,与对照组相比有统计学意义(P<0.05),血清中HDL-C含量与对照组相比显著升高(P<0.05),血清中TC的剂量效应曲线呈γ型.②染砷大鼠肝脏中cAMP、cGMP含量均显著高于对照组(P<0.05),且肝脏中NO含量明显升高,有剂量反应关系,与对照组相比差异有显著意义(P<0.05).③光镜观察可见染砷组肝汇管区内有炎性细胞浸润,肝细胞发生脂肪变性和嗜酸性变性;电镜观察发现肝细胞内有脂滴,线粒体肿胀,膜破坏,粗面内质网肿胀,脱颗粒.结论砷可使脂代谢发生紊乱,出现这种情况可能与体内NO含量增多,第二信使系统平衡紊乱,肝细胞超微结构受到破坏,使脂质的分解、合成、转运等多环节出现障碍有关." @default.
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- W3030485056 date "2003-03-20" @default.
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- W3030485056 title "The characterization of the blood lipid spectrum in subchronic arsenic-poisoning rats and it's mechanism" @default.
- W3030485056 doi "https://doi.org/10.3760/cma.j.issn.1000-4955.2003.02.004" @default.
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