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- W3030486520 abstract "Objective To evaluate the therapeutic effects of Ag85A and Ag85B recombination protein vaccines combined with adjuvant in mouse model of Mycobacterium tuberculosis infection to establish new immunotherapeutic agents to treat tuberculosis.Methods 60 female BALB/c mice were infected intravenously via the tail vein with Mycobacterium tuberculosis H37RV,then randomly divided into six groups based and treated as follow at the third day after infection:saline,rifampin,Mycobacterium Phlei F.U.36 injection,adjuvant,Ag85A and Ag85B recombinat protein vaccines,Ag85A and Ag85B recombinat protein vaccines combined with adjuvant.Vaccines were injected intramuscularly three times at two-week intervals.Mice were sacrificed two weeks after the final immunization.The lungs and spleens from the mice were taken and their pathological changes,weight and number of mycobacterial colony were examined.Results The histopathological changes of lung showed that the lung lesions were severe and extensive in saline and adjuvant group,the lung lesions were slight and limited,there were relatively clearand normal structure of alveoli in Mycobacterium Phlei F.U.36 injection,adjuvant,Ag85A and Ag85B recombinatprotein vaccines,Ag85A and Ag85B recombinat protein vaccines combined with adjuvant group,there were no lung lesions in rifampin group.Compared with saline group,pulmonary bacterial loads of rifampin group,Mycobacterium Phlei F.U.36 injection group,Ag85A and Ag85B recombinat protein vaccines combined with adjuvant group reduced by 2.11 log,0.76 log,and 0.57 log,liver bacterial loads by 2.11 log,0.74 log,and 0.44 log (t ＞ 3.21,P ＜ 0.01),respectively.Conclusions The immunotherapeutic effect of Ag85A and Ag85B recombinat protein vaccines combined with adjuvant is significant in the mouse model of tuberculosis,as that as Mycobacterium Phlei F.U.36 injection.Key words: Mycobacterium tuberculosis ; Ag85A ; Ag85B; Protein ; Therapy" @default.
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- W3030486520 date "2014-05-20" @default.
- W3030486520 modified "2023-10-06" @default.
- W3030486520 title "Therapeutic effects of Ag85A and Ag85B recombinat protein vaccines from Mycobacterium tuberculosis combined with adjuvant" @default.
- W3030486520 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2014.010.004" @default.
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