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- W3030487664 abstract "第九讲肿瘤的表遗传学改变(2) 1 组蛋白修饰及其在癌细胞中的改变 1.1 染色质结构功能状态与组蛋白修饰真核细胞DNA的生理状态是染色质,是由DNA、组蛋白和非组蛋白组成的核蛋白.染色质结构的基本单位是核小体,该复合物是146 bp的基因组DNA围绕核心组蛋白八聚体而成,八聚体是由1个H3-H4四聚体和两个H2A-H2B二聚体组成;连接组蛋白H1则把核小体连接起来,成为纤丝状的染色质.除常见组蛋白外,还存在一些组蛋白变体如H2A.X,也与基因组功能状态密切相关.组蛋白是真核细胞DNA主要结合蛋白,也是已知进化上最保守的蛋白,是一些小分子碱性蛋白,其中带正电荷的氨基酸,如赖氨酸和精氨酸的含量较高[1-3]。" @default.
- W3030487664 created "2020-06-05" @default.
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- W3030487664 date "2011-06-15" @default.
- W3030487664 modified "2023-09-25" @default.
- W3030487664 title "Cancer epigenetics(continued 9-2)" @default.
- W3030487664 doi "https://doi.org/10.3760/cma.j.issn.1673-4386.2011.03.010" @default.
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