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- W3030489002 abstract "Objective To evaluate the effect of the method with MSCs interventional therapy on os-teonecrosis of the femoral head (ONFH). Methods Eighteen adult Beagle canines were randomized divided into three groups: A (control group), B (Yougui drink group), C (artery perfusion with MSCs group). The model of ONFH was set up through the method of liquid Nitrogen cryopreservation. At the mean time, MSCs were derived, cultured, proliferated and marked. Three weeks after modeling, Yougui drink (100 ml per ani-mal) was given to the canines in group B by the intragastric administration, distilled water was given to those in group A and group C, respectively. Those in group C were administrated 1 ml MSCs per animal with artery perfusion (5×106-1×107/ml). Those in group A and B were treated with normal saline. At 4 and 8 weeks after continuous treatment, changes of the femoral head were evaluated by methods of gross observation, MRI, his-tologic observation, immunohistochemistry and RT-PCR. Results The quantity and diameter of vessel in group C were significantly better than before therapy. Histologic observation showed that articular cartilage, morphology and structure of trabecular bone in group B and C were better than group A. Immunohistochemistry showed that the VEGF positive staining in group C was significantly higher than in group A and B. The expression of VEGF, TGF-β, OPG genes in group C was higher than in group A and B by RT-PCR. Conclu-sion The method of MSCs interventional therapy, which were performed with artery perfusion seemed to have some therapeutic effect on ONFH. It can improve the blood supply and accelerate repair of femoral head. The final results of this animal study can offer the effective clinical theoretical foundation for the heal-ing of the early stage of ONFH and the prevention of collapse of femoral head.Key words: Femur head necrosis; Mesenchymal stem cell transplantation; Yougui drink" @default.
- W3030489002 created "2020-06-05" @default.
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- W3030489002 date "2010-06-01" @default.
- W3030489002 modified "2023-09-24" @default.
- W3030489002 title "An experimental study on treatment of osteonecrosis of the femoral head with MSCs interventional therapy" @default.
- W3030489002 doi "https://doi.org/10.3760/cma.j.issn.0253-2352.2010.06.013" @default.
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