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- W3030489022 abstract "Objective To evaluate the impact of lycopene on cell proliferation and androgen receptor gene activity of primary prostate epithelial cells.Methods Lycopene at concentrations of 1,5,10 μmol/L was added to the isolated primary prostate epithelial cells and the impact on cell proliferation was analyzed by using immunofluorescent method.A transient transfection of a plasmid DNA recombinant containing androgene receptor element-luciferase (ARE-Luc) report gene into primary prostate epithelial cells was developed and the impact of different concentrations of lycopene on androgen receptor element was evaluated by using quantative analysis of luciferse enzyme product.Results Lycopene ( 1,5,10μmol/L)could inhibit cell growth by 3.04%,6.88% and 18.42% ( P ＜ 0.01 ) respectively as compared with PrEBM media.As compared with 1% THF solvent,the proliferation in lycopene-treated groups (5,10μmol/L) was inhibited by 3.86% and 15.40% ( P ＜0.05 ) respectively.The results of transient transfection and luminometer data showed that luminometer data were decreased by 52.38%,68.10% and 95.24% respectively when 1,5,10 μmol/L lycopene was added.Conclusion Lycopene inhibits cell proliferation and androgen receptor gene element activity in primary prostate epithelial cells in a dose-dependent manner.Key words: Lycopene; Prostate epithelial cells; Androgene receptor; Luciferase enzyme" @default.
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- W3030489022 date "2010-12-08" @default.
- W3030489022 modified "2023-09-24" @default.
- W3030489022 title "Lycopene inhibiting cell proliferation and androgen receptor gene element activity in primary prostate epithelial cells" @default.
- W3030489022 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2010.12.012" @default.
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