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• W3030492658 abstract "Abstract Objectives Malignant high-grade gliomas are the most common and aggressive type of primary brain tumor. We aimed to evaluate the prognostic value of modified Glasgow Prognostic Score (mGPS), which is combination of C-reactive protein (CRP) and albumin, in recurrent high-grade glioma patients treated with systemic treatment. Patients and Methods Data of 85 patients with recurrent high-grade glioma who received systemic treatment and followed in our clinic between 2012 and 2018 was retrospectively collected and analyzed. Patients were grouped according to mGPS criteria: mGPS-0: CRP 3.5 g/dL; mGPS-1: CRP 10 mg/L and albumin >3.5 g/dL; and mGPS-2: CRP > 10 mg/L and albumin Results There were 42 (49.4 %), 25 (29.6 %), and 18 (21 %) patients in mGPS-0, mGPS-1, and mGPS-2 groups, respectively. Median follow-up duration was 10 months (1–70 months). Median OS was 8.1 months. According to mGPS-0, -1 and -2; median OS was 13.8 months, 7.3 months and 3.6 months respectively (p = 0.003). mGPS, ATRX and IDH-1 mutation status, and ECOG PS were found to be independent prognostic factors for OS. Conclusion In our study, mGPS was found to be an independent prognostic factor in patients with recurrent high-grade gliomas. If validated, mGPS can be used as an objective, easily calculated, cheap, and readily available prognostic model in routine practice." @default.
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• W3030492658 date "2020-09-01" @default.
• W3030492658 modified "2023-09-26" @default.
• W3030492658 title "Prognostic value of modified Glasgow prognostic score in recurrent high-grade glial tumors treated with systemic treatment" @default.
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• W3030492658 doi "https://doi.org/10.1016/j.clineuro.2020.105976" @default.
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