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- W3030502073 abstract "Caspases (Cysteine-dependent aspartate-specific proteases) are a family of cysteine proteases that play important roles in regulating apoptosis.Recent studies have shown that some caspases related to apoptosis also participate in the activation and proliferation of T lymphocytes.This can be reflected in three aspects:several caspases were detected in the activation and proliferation of T lymphocytes; inactivation of caspase-8 in vivo resulted in T cell immune deficiency in both human and mouse; in vitro proliferation and activation of T lymphocytes,induced by anti-CD3 monoclonal antibody or superantigen could induce were blocked when caspase inhibitor was added at the same time.In vivo investigations have confirmed the anti-immune and anti-inflammatory effects of caspase inhibitor,These studies provided new approach for the treatment of immune and inflammatory for the development of new anti-immune and anti-inflammatory drugs.Key words: Caspase; Caspase inhibitor; Activation of T lymphocyte; Proliferation of T lymphocyte" @default.
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- W3030502073 date "2012-01-05" @default.
- W3030502073 modified "2023-09-28" @default.
- W3030502073 title "Role of caspases in activation and proliferation of T lymphocytes" @default.
- W3030502073 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2012.01.006" @default.
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