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• W3030523933 endingPage "408" @default.
• W3030523933 startingPage "377" @default.
• W3030523933 abstract "Abstract Microcephaly refers to a “small head” or “small brain.” Patients who present with this condition often have accompanying intellectual disability and other neurological conditions. The microcephalies can be conveniently divided into those that are congenital (also referred to as primary), presenting before birth, and postnatal (or secondary), when the head size is normal at birth but gradually falls off normal growth curves. Multiple etiologies exist for microcephaly, including genetic mutations, infections (e.g., Zika virus, CMV, and toxoplasmosis), and environmental/toxin (e.g., drugs or alcohol) exposure during pregnancy. Recent studies have identified a wide range of genetic defects in various cellular processes (e.g., centrosome/centriole function related to spindle formation, DNA replication and repair, chromosome assembly and separation, cytokinesis, cell cycle regulation, vesicle trafficking, transcription, and signaling), implicating a diverse group of pathogenic mechanisms underlying the etiology of microcephaly. Studying microcephaly has also provided new insights into the developmental regulation of brain size." @default.
• W3030523933 created "2020-06-05" @default.
• W3030523933 creator A5009572751 @default.
• W3030523933 creator A5023262210 @default.
• W3030523933 date "2020-01-01" @default.
• W3030523933 modified "2023-10-18" @default.
• W3030523933 title "Congenital and postnatal microcephalies" @default.
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