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- W3030529797 abstract "Standardni lecebnou modalitou pro premenopauzalni pacientky s nadorem SR+ a HER2- je hormonoterapie. I nadale zůstava soucasti adjuvantni HT tamoxifen. Byl potvrzen přinos ovarialni ablace, nejenom v kombinaci s tamoxifenem, ale nově je u premenopauzalnich pacientek středniho a vysokeho rizika možno podat i exemestan spolu s ovarialni ablaci. Delka adjuvantni HT se prodlužuje, u drobných nadorů je možno podavat HT pouze 5 let, u ostatnich by měla být delka adjuvantni HT minimalně 5 let, u nadorů s pozitivitou axilarnich uzlin byl prokazan benefit 10leteho uživani. Nově se staly standardni soucasti děleni na jednotlive prognosticke skupiny i multigenove testy. U metastatickeho onemocněni je na prvnim mistě zajistěni menopauzy a nasledně se terapie nelisi od lecby postmenopauzalnich pacientek. K dispozici jsou antiestrogeny – tamoxifen a fulvestrant, inhibitory aromataz v kombinaci s inhibitory cyklin-dependentnich kinaz, popř. s everolimem. Využivany jsou preparaty, u kterých nedoslo k progresi v adjuvantnim podani." @default.
- W3030529797 created "2020-06-05" @default.
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- W3030529797 date "2019-03-15" @default.
- W3030529797 modified "2023-10-18" @default.
- W3030529797 title "Hormonal therapy in premenopausal patients with SR-positive, HER2-negative breast cancer" @default.
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- W3030529797 doi "https://doi.org/10.36290/xon.2019.005" @default.
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