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- W3030531567 abstract "ObjectiveTo examine the association of newly identified obesity-related genes' SNPs with obesity in Chinese children.MethodsA total of 201 Chinese children with obesity were selected as research subjects from January to September 2010. One hundred eighty three healthy adult blood donors were selected as normal controls. Mass spectrometry techniques were used to study the distributions of the alleles and genetype of newly identified obesity susceptibility loci in patients and controls. And the relationship between newly identified obesity-related loci gene polymorphism and obesity in Chinese children were studied.ResultsThe distributions of three gene polymorphisms (rs7138803 of FAIM2 gene, A frequency of alleles in the obesity group was obviously higher than that of normal control group (35.5% to 26.5%), two groups compare difference was statistically significant (χ2=6.94, P=0.0084); rs10838738 of MTCH2 gene, G frequency of alleles in the obesity group was obviously higher than that of normal control group (35.3% to 27.7% ), two groups compare difference was statistically significant (χ2=5.04, P=0.0248); and rs7647305 of ETV5 gene, C frequency of alleles in the obesity group was obviously higher than that of normal control group (94.3% to 90.5%)two groups compare difference was statistically significant (χ2=3.93, P=0.0475)) in obesity patients and healthy controls have significant differences. And the distributions of genetypes (rs7138803 of FAIM2 gene) in obesity patients and healthy controls have significant differences.ConclusionThe gene polymorphisms of rs7138803 of FAIM2 gene, rs10838738 of MTCH2 gene and rs7647305 of ETV5 gene confer significant susceptibility to obesity in Chinese children.Key words: Obesity; Gene polymorphism; Allele; Genotype" @default.
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- W3030531567 date "2015-09-27" @default.
- W3030531567 modified "2023-10-07" @default.
- W3030531567 title "Association of newly identified obesity-related genes' single nucleotide polymorphisms with obesity in Chinese children" @default.
- W3030531567 doi "https://doi.org/10.3760/cma.j.issn.1674-5809.2015.09.008" @default.
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