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- W3030536085 endingPage "3383" @default.
- W3030536085 startingPage "3374" @default.
- W3030536085 abstract "Abstract Metformin has undisputed glucose-lowering effects in diabetes and an impressive safety record. It has also shown promising effects beyond diabetes, and several hundred clinical trials involving metformin are currently planned or active. Metformin targets intracellular effectors, but exactly which remain to be established, and in an era of precision medicine, an incomplete understanding of mechanisms of action may limit the use of metformin. Distribution of metformin depends on specific organic cation transporter proteins that are organ- and species-specific. Therefore, target tissues of metformin can be identified by cellular uptake of the drug, and exploring the biodistribution of the drug in humans becomes an attractive strategy to assist the many investigations into the mechanisms of action of metformin performed in animals. In this review, we combine the emerging evidence from the use of 11C-labeled metformin in humans to discuss metformin action in liver, intestines, and kidney, which are the organs with the most avid uptake of the drug." @default.
- W3030536085 created "2020-06-05" @default.
- W3030536085 creator A5004351055 @default.
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- W3030536085 creator A5064270055 @default.
- W3030536085 creator A5069773948 @default.
- W3030536085 creator A5081485513 @default.
- W3030536085 date "2020-06-01" @default.
- W3030536085 modified "2023-10-11" @default.
- W3030536085 title "Metformin Biodistribution: A Key to Mechanisms of Action?" @default.
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