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- W3030540888 abstract "Objective To evaluate the effect of dexmedetomidine (Dex) on glial fibrillary acidic protein (GFAP) and brain typeisoenzyme of creatine phosphokinase (CK-BB) concentration during perioperative period in patients with meningioma,and to evaluate the cerebral protection function of Dex during surgery.Methods Forty-five ASA Ⅱ or Ⅲ patients with meningioma aged 45 y-65 y weighing 55 kg-65 kg scheduled for elective intracranial tumor recection were randomly divided into 3 groups (n=15):control group (group C),low-dose Dex group (0.2 μg·kg-1·h-1,group D1),high dose Dex group 0.5 μg·kg-1·h-1(group D2).Dex was intravenously infused 10 min before induction at the dose of 1 μg/kg,followed by constant speed infusion at 0.2 μg·kg1·h-1 and 0.5μg·kg-1·h-1 in grgup D1 and D2 respectively until 30 min before the end of the operation.Group C received the same volume of saline.Bispectral index (BIS) was maintained at 40-49.Venous blood samples were taken for determination of serum concentrations of GFAP and CK-BB respectively before induction (T1),at the time of dislodging tumor (T2),during extubating trachea (T3) and 24 h after operation(T4).Blood samples were also collected from left radial artery and right jugular venous bulb for blood gas analysis to calculate the arterial oxygen content(CaO2),cerebral arterial venous oxygen content difference(Da-jvO2),cerebral extraction of oxygen(CEO2).Results Compared with T1,the concentration of GFAP and CK-BB in serum and CEO2 significantly increased at T2-T4 in all of the groups (P＜0.05).There was significant difference between group C and group D2 in the concentration of GFAP and CK-BB in serum at T2-T4(P＜0.05),The numerical values of GFAP in serum in group C were[(0.72±0.05),(0.80-±0.05),(0.90±0.05) μg/L],while that of group D2 were [(0.78±0.06),(0.88±0.07),(1.17±0.19) μg/L],respectively at T2-T4.The numerical values of CK-BB in serum in group C were [(30.6±2.6),(33.2±3.4),(36.1±2.8) U/L],while that of group D2 were [(19.3±1.8),(21.1±2.4),(23.5±2.8) U/L],respectively at T2-T4.There was significant diferenee in the three groups about CEO2 at T2-T3(P＜0.05),The numerical values of CEO2 in group C were [(0.36±0.03)％,(0.34±0.03)％],while that of group D1 were [(0.33±0.04)％,(0.30±0.04)％],and group D2 were [(0.32±0.04)％,(0.26 ±0.04)％],respectively at T2-T3.Conclusions Intraoperative infusion of dexmedetomidine may play a protective effect on (role in) patients with meningioma,The mechanism may be associated with lowering plasma GFAP and CK-BB concentrations and cerebral oxygen uptake rate.Key words: Dexmedetomidine; Neuroprotection; Meningioma; Cerebral extraction of oxygen" @default.
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- W3030540888 date "2014-09-15" @default.
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- W3030540888 title "The effects of dexmedetomidine on glial fibrillary acidic protein and brain typeisoenzyme of creatine phosphokinase during perioperative period in patients with meningioma" @default.
- W3030540888 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2014.09.010" @default.
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