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- W3030545303 abstract "Objective To examine the expression of CXC chemokine receptor 2 (CXCR2) in human hepatoeellular carcinoma (HCC), and determine its role in tumorigenesis and progression of HCC.Methods CXCR2 mRNA and protein expression in 42 specimens of HCC and adjacent liver tissues,23 of normal liver tissues was examined by using semi-quantitative reverse transcription-PCR and Western blot.Results The expression levels of CXCR2 mRNA and protein in HCC, adjacent and normal liver tissues were 1.18 ± 0.32,0.83 ± 0.23 and 0.72 ± 0.23, and 1.78±0.20,0.98±0.13 and 0.90 ± 0.18 respectively.As compared with adjacent and normal liver tissues, the expression levels of CXCR2 mRNA and protein in HCC tissues were significantly increased (P <0.05).The expression levels of CXCR2 mRNA and protein in groups with intrahepatic metastasis, portal vein tumor thrombus and low differentiation were 1.37 ± 0.26,1.45 ± 0.34 and 1.31 ± 0.28, and 1.87 ± 0.20,1.93 ± 0.13 and 1.86 ± 0.18 respectively, and those in groups without intrahepatic metastasis, portal vein tumor thrombus and high differentiation were 1.08 ± 0.33,1.08 ± 0.27 and 1.06 ± 0.33, and 1.73 ± 0.18,1.73 ± 0.20 and 1.71 ± 0.19, with the difference being significant (P < 0.05).Furthermore, the protein level of CXCR2 was relevant to TNM staging.The protein levels of CXCR2 in stage Ⅲ -Ⅳ and stage Ⅰ - Ⅱ were 1.86 ± 0.20 and 1.72 ± 0.19, with the difference being significant (P < 0.05).Conclusion CXCR2 was highly expressed in HCC tissue.CXCR2 might play a role in the tumorigenesis,invasion and metastasis of HCC.Key words: Carcinoma,hepatocellular; Chemokine; Expression" @default.
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- W3030545303 date "2009-08-08" @default.
- W3030545303 modified "2023-09-24" @default.
- W3030545303 title "Significance and expression of CXC chemokine receptor 2 in human hepatocellular carcinoma" @default.
- W3030545303 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2009.08.010" @default.
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