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- W3030548875 abstract "ObjectiveTo explore the relevance between 18F-FDG PET-CT imaging features and laboratory parameters of multiple myeloma (MM) and its prognostic value.MethodsThe clinical data of 75 MM patients who received 18F-FDG PET-CT examination at the time of initial diagnosis in Tianjin Medical University Cancer Institute & Hospital from September 2008 to August 2016 were retrospectively analyzed, including their clinical features, survival time, PET-CT imaging and laboratory results. The correlation between imaging changes and laboratory results was analyzed. Kaplan-Meier method and log-rank test were used to make survival analysis.ResultsOf 75 patients, there were 48 patients (64.0%) who had lytic bone lesions everywhere of the bodies, especially in axial skeleton. Twenty-six patients (34.7%) had pathological fracture, which were either rib or spinal pathologic fracture. PET-CT at initial diagnosis showed that the osteolytic lesions were associated with anemia (χ 2 = 0.455, P = 0.032), while pathological fractures were associated with C-reactive protein levels (χ 2 = 0.976, P = 0.007). The existence of pathologic fracture or lytic bone lesions showed no relevance to abnormal cytogenetics, extramedullary lesion, lactic dehydrogenase, albumin or β2-macroglobulin (β2-MG) levels as well as the survival time (all P > 0.05). Twenty-eight patients (37.3%) with extramedullary lesions were found to have higher expression of β2-MG than those without extramedullary lesions, and the progression-free survival (PFS) and overall survival (OS) rates were lower than those without extramedullary lesions (all P 0.05).ConclusionsThe results at initial diagnosis show that the osteolytic lesions and pathological fractures detected by 18F-FDG PET-CT have a certain correlation with the results of laboratory tests, which can be used as indirect indicators for the judgement of prognosis. Extramedullary lesions is an independent poor prognostic factor affecting OS in MM patients.Key words: Multiple myeloma; Fluorodeoxyglucose F18; Positron-emission tomography; Laboratory examination; Prognosis" @default.
- W3030548875 created "2020-06-05" @default.
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- W3030548875 date "2019-08-25" @default.
- W3030548875 modified "2023-09-24" @default.
- W3030548875 title "Value of 18F-FDG PET-CT imaging features in the prognosis evaluation of newly diagnosed patients with multiple myeloma" @default.
- W3030548875 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2019.08.002" @default.
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