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- W3030572893 abstract "目的 利用小发卡环RNA(shRNA)使缺氧培养条件下的人视网膜色素上皮(RPE)细胞缺氧诱导因子1α(HIF-1 α)基因沉默,观察对血管内皮生长因子(VEGF)及色素上皮衍生因子(PEDF)的影响.方法 体外转录法合成对HIF-1 α mRNA序列的两个靶点的shRNA,对缺氧(150 μmol/L CoCl2模拟)培养条件下人RPE细胞的HIF-1 α进行干扰,使用RT-PCR检测HIF-1 α、VEGF和PEDF mRNA的表达及Western印迹分析检测HIF-1 α、VEGF和PEDF蛋白水平.结果 HIF-1 α mRNA的两种shRNA均能有效地抑制RPE细胞在缺氧条件下HIF-1 α的表达,同时也有效地抑制VEGF mRNA和蛋白表达,并促进PEDF蛋白表达,但对PEDF mRNA的表达无影响.结论 HIF-1 α mRNA的shRNA能有效地使缺氧条件下RPE细胞HIF-1 α基因沉默,进而有效地抑制缺氧对VEGF的上调作用,同时也促进PEDF表达.揭示了HIF-1与缺氧条件下PEDF翻译后的下调机制有关,是促进视网膜新生血管形成最为关键的细胞因子之一。" @default.
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- W3030572893 date "2007-09-15" @default.
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- W3030572893 title "Downregulation of VEGF and upregulation of PEDF in human RPE cells under hypoxia condition by shRNA inhibiting the expression of HIF-1 α" @default.
- W3030572893 doi "https://doi.org/10.3760/cma.j.issn.2095-0160.2007.09.013" @default.
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