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• W3030582014 abstract "Virulent strains of West Nile virus (WNV) are highly neuro-invasive and human infection is potentially lethal. However, no vaccine is currently available for human use. Here, we report the immunogenicity and protective efficacy of a vaccine derived from a chimeric virus, which was constructed using the structural proteins (prM and E) of the Kunjin strain of WNV (WNVKUN) and the genome backbone of the insect-specific flavivirus Binjari virus (BinJV). This chimeric virus (BinJ/WNVKUN-prME) exhibits an insect-specific phenotype and does not replicate in vertebrate cells. Importantly, it authentically presents the prM-E proteins of WNVKUN, which is antigenically very similar to other WNV strains and lineages. Therefore BinJ/WNVKUN-prME represents an excellent candidate to assess as a vaccine against virulent WNV strains, including the highly pathogenic WNVNY99. When CD1 mice were immunized with purified BinJ/WNVKUN-prME, they developed robust neutralizing antibody responses after a single unadjuvanted dose of 1 to 5 μg. We further demonstrated complete protection against viremia and mortality after lethal challenge with WNVNY99, with no clinical or subclinical pathology observed in vaccinated animals. These data suggest that BinJ/WNVKUN-prME represents a safe and effective WNV vaccine candidate that warrants further investigation for use in humans or in veterinary applications." @default.
• W3030582014 created "2020-06-05" @default.
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• W3030582014 date "2020-05-29" @default.
• W3030582014 modified "2023-09-23" @default.
• W3030582014 title "Protective Efficacy of a Chimeric Insect-Specific Flavivirus Vaccine against West Nile Virus" @default.
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• W3030582014 doi "https://doi.org/10.3390/vaccines8020258" @default.
• W3030582014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7349994" @default.
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