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- W3030586185 abstract "Objective The purpose of this randomized trial is to compare the efficacy and toxicity of irinotecan plus cisplatin(IP) with EP as the first-line chemotherapy.Methods A total of 61 patients with SCLC were randomly divided into arm IP (irinotecan 80 mg/m2,d1,8 ; cisplatin 25 mg/m2,d1-3,21 d/cycle) and arm EP(etoposide 100 ng/m2,cisplatin 25 mg/m2,d1-3,21 d/cycle).38 patients(62.3％) were staged Ⅲ according to 7th UICC TNM staging,23 were staged Ⅳ.All patients completed 4 cycles chemotherapy,18 patients altered regimen while no response was found after 2 cycles.Results The total objective response rate (ORR) was 82.0％,74.2％ (IP) vs.66.7％ (EP)(P =0.582),the rate complete response(CR) with IP and EP was 51.6％ and 26.7％,respectively (P =0.033).7 patients(38.9％) experienced partial response after altered regimen,there was no difference between IP and EP(2/8 vs 5/10,P =0.367).The common adverse effects included neutropenia (75.6％),diarrhea (46.3％),and vomiting (41.5％) of IP,vomiting(71.1％),neutropenia (68.4％) and anemia(28.9％) of EP,the morbidity of diarrhea was higher of IP than EP(46.3％ vs.10.5％,P ＜ 0.01).Conclusions IP regimen cause a higher rate of CR than EP for SCLC,a higher morbidity of diarrhea too,the adverse effects can be tolerated by appropriate treatment.Key words: Small cell lung cancer ; Hemotherapy ; Etoposide ; Irinotecan" @default.
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- W3030586185 date "2012-10-25" @default.
- W3030586185 modified "2023-09-27" @default.
- W3030586185 title "A randomized trial of irinotecan plus cisplatin compared with etoposide plus cisplatin for the first-line chemotherapy of small cell lung cancer" @default.
- W3030586185 doi "https://doi.org/10.3760/cma.j.issn.1674-4756.2012.20.007" @default.
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