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- W3030607304 abstract "Graves眼病(GO)主要与细胞免疫反应有关,自身抗原包括促甲状腺素受体、G2s蛋白和黄素蛋白、23KD蛋白和胶原Ⅻ、甲状腺球蛋白等.CD4+T淋巴细胞和巨噬细胞浸润球后组织,并被激活,分泌Th1细胞因子、氧自由基和致纤维化生长因子,导致眼眶炎症反应,刺激成纤维细胞增殖、分泌糖胺多糖,使眼外肌肿胀,并刺激部分前脂肪细胞分化为脂肪细胞.Th2细胞因子刺激B淋巴细胞活化,产生自身抗体.除T淋巴细胞外,成纤维细胞在GO自身免疫反应中既是靶细胞,又是效应细胞." @default.
- W3030607304 created "2020-06-05" @default.
- W3030607304 creator A5004365834 @default.
- W3030607304 creator A5081154303 @default.
- W3030607304 date "2002-03-20" @default.
- W3030607304 modified "2023-09-25" @default.
- W3030607304 title "Graves眼病的发病机理" @default.
- W3030607304 doi "https://doi.org/10.3760/cma.j.issn.1673-4157.2002.02.012" @default.
- W3030607304 hasPublicationYear "2002" @default.
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