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- W3030607995 abstract "A 30-year-old female patient received oral rifampicin 0.562 5 g (before breakfast) and isoniazid 0.4 g (after dinner) for pulmonary tuberculosis. There were no abnormalities in her blood routine and liver function indexes before medication. Three days after the medication, the patient developed fatigue, nausea, and vomiting. The next-day laboratory tests showed white blood cell count 1.1×109/L, neutrophil count 0.32×109/L, hemoglobin (Hb) 120 g/L, platelet count (PLT) 149×109/L, alanine aminotransferase (ALT) 368 U/L, aspartate aminotransferase (AST) 1 333 U/L, total bilirubin (TBil) 19.7 μmol/L, and direct bilirubin (DBil) 6.6 μmol/L. Liver injury and neutropenia were diagnosed. Considering the reason from current medication, rifampicin and isoniazid were discontinued and liver-protective and symptomatic treatments were given. On day 4 of the withdrawal, the patient′s symptoms improved and laboratory tests showed neutrophil count 1.50×109/L, ALT 163 U/L, AST 139 U/L, TBil 9.0 μmol/L, and DBil 3.7 μmol/L. On day 7 of the withdrawal, the patient′s liver function improved (ALT 75 U/L, AST 33 U/L, TBil 6.4 μmol/L, and DBil 3.3 μmol/L) and her neutrophil count was 1.60×109/L. One week after discharge, the neutrophil count was 1.70×109/L; the levels of ALT, AST, TBil, and DBil were 30 U/L, 34 U/L, 10.0 μmol/L, and 4.2 μmol/L, respectively .Key words: Isoniazid; Rifampin; Antitubercular agents; Chemical and drug induced liver injury; Neutropenia" @default.
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- W3030607995 date "2019-10-28" @default.
- W3030607995 modified "2023-09-27" @default.
- W3030607995 title "Acute liver injury and neutropenia due to antitubercular agents" @default.
- W3030607995 doi "https://doi.org/10.3760/cma.j.issn.1008-5734.2019.05.017" @default.
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