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- W3030609540 abstract "ObjectiveTo investigate the effect of autologous peripheral blood stem cell transplantation combined with CD34+ cells and oral sarpogrelate hydrochloride for the treatment of vascular reconstruction and blood supply on the thromboangiitis obliterans.MethodsThromboangiitis obliterans (TAO) of 262 patients with 262 lower limbs were divided into stem cells CD34+ cells transplantation combined with sarpogrelate hydrochloride group (group A) with 100 lower limbs, CD34+ stem cell transplantation group (group B) with 91 lower limbs, and sarpogrelate hydrochloride oral group ( group C) with 71 lower limbs. The degree of lower limb local blood flow variability were calculated at the three levels of skin, blood vessels and blood by preoperative and postoperative use of multi-function monitoring instrument, Doppler detector, transcutaneous oxygen pressure monitor, and digital subtraction angiography (DSA), respectively.Results⑴ The degree of shank, foot cyanosis, cool skin, and pain was relieved significantly in groups A and B than in group C for 1 month after the treatment (P<0.05). ⑵ Intermittent claudication distance, the skin temperature of the lower leg and foot to patients in the groups A and B than in group C, with a significant difference (F=7.01, F=7.04, P<0.05) for 3 months after the treatment. ⑶ Among the patients with amputation, 10 cases were in group A, 16 cases in group B, and 31 cases in group C for 6 months after the treatment. ⑷ Transcutaneous oxygen pressure was increased from (30.43±4.31)mmHg to (37.21±9.01)mmHg (F=5.69, P<0.05), ankle brachial index from (0.32±0.23) to (0.91 ± 0.16) (F=6.71, P<0.05), the volume of blood flow index from the photoelectric (0.22±0.04) to (0.83±0.13 (F=5.69, P<0.05), oxygen saturation from (42.41±9.61)% to (79.61±20.34)% (F=5.74, P<0.05), and DSA score (0.23±0.03) increased to (1.35±0.23) (F=7.14, P<0.05), which was significantly higher than group B and group C (F=7.01, F=7.04, F=7.12, F=7.08, F=7.15, P<0.05) for one year after treatment.ConclusionsTreatment of peripheral blood stem cells CD34+ cell transplantation combined with oral sarpogrelate hydrochloride can significantly improve the vascular regeneration and its blood supply in TAO lower extremity limb.Key words: Peripheral blood stem cell transplantation; Antigens, CD34/AD; Platelet aggregation inhibitors/AD; Thromboangiitis obliterans/TH; Blood circulation" @default.
- W3030609540 created "2020-06-05" @default.
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- W3030609540 date "2017-12-20" @default.
- W3030609540 modified "2023-09-26" @default.
- W3030609540 title "Study on the efficacy of CD34+ cells combined with sarpogrelate hydrochlotride tablets for the reconstruction of the blood supply of thromboangiitis obliterans" @default.
- W3030609540 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2017.12.009" @default.
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