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- W3030609569 abstract "ObjectiveTo investigate the relationship between vascular endothelial growth factor C (VEGF-C) and lymphatic vessel density (LVD) with clinicopathological features of the patients in stage Ⅱ colorectal cancer.MethodsFifty-seven tissues in stage Ⅱ colorectal cancer and 57 normal mucosal tissues in Shaanxi Provincial Cancer Hospital from January 2005 to December 2010 were collected. The expression of VEGF-C and LVD were detected by using immunohistochemical method. The relationship between VEGF-C and LVD with the clinicopathological features of colorectal cancer was analyzed.ResultsThe expression of VEGF-C and LVD in cancer tissues was higher than that in normal tissues (6.80±1.24 vs. 2.07±0.17, t = 3.773, P = 0.000; 3.19±0.53 vs. 1.84±0.26, t = 2.276, P = 0.025). There were statistical differences between VEGF-C and LVD in different tumor diameter (4.00±0.54 vs. 11.26±2.89, t = -3.049, P = 0.004; 1.89±0.37 vs. 5.27±1.12, t = -3.376, P = 0.001) and relapse or metastasis (4.74±1.31 vs. 10.62 ±2.39, t = -2.158, P = 0.039; 1.86±0.45 vs. 5.65±1.06, t = -3.778, P = 0.000). LVD in VEGF-C positive group was higher than that in VEGF-C negative group (4.16±0.64 vs. 0.21±0.11, t = 3.503, P = 0.001). The expression of VEGF-C was positively correlated with LVD (r = 0.892, P = 0.000).ConclusionsThe expression of VEGF-C in stage Ⅱ colorectal cancer is correlated with LVD, as well as tumor size and relapse or metastasis. VEGF-C and LVD could also play important roles in the occurrence, development and metastasis in stage Ⅱ colorectal cancer.Key words: Colorectal neoplasms; Vascular endothelial growth factor C; Lymphatic vessels density" @default.
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- W3030609569 date "2018-07-28" @default.
- W3030609569 modified "2023-09-26" @default.
- W3030609569 title "Relationship between vascular endothelial growth factor C and lymphatic vessel density with clinicopathological features of the patients in stage IIcolorectal cancer" @default.
- W3030609569 doi "https://doi.org/10.3760/cma.j.issn.1006-9801.2018.07.007" @default.
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