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- W3030619473 abstract "Ouratea spectabilis is an arborous species traditionally used in Brazil as an anti-inflammatory agent. Four new (3,3″)-linked biflavanone O-methyl ethers, named ouratein A (1), B (2), C (3), and D (4), were isolated from the bark extract of the species. Ouratein A (1) is an enantiomer of neochamagesmine A, which has never been described before. The structures were elucidated by extensive spectroscopic data analyses, whereas their absolute configurations were defined by electronic circular dichroism data. Ouratein D (4) inhibited in vitro the release of the pro-inflammatory cytokine CCL2 by lipopolysaccharide-stimulated THP-1 cells (IC50 of 3.1 ± 1.1 μM), whereas TNF and IL-1β release were not reduced by any of the biflavanones. These findings show ouratein D (4) as a selective CCL2 inhibitor, which may have potential for the development of new anti-inflammatory agents to prevent or treat cardiovascular diseases." @default.
- W3030619473 created "2020-06-05" @default.
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- W3030619473 date "2020-06-02" @default.
- W3030619473 modified "2023-09-23" @default.
- W3030619473 title "(3,3″)-Linked Biflavanones from <i>Ouratea spectabilis</i> and Their Effects on the Release of Proinflammatory Cytokines in THP-1 Cells" @default.
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- W3030619473 doi "https://doi.org/10.1021/acs.jnatprod.0c00074" @default.
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