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- W3030626768 abstract "目的 探讨血液滤过(CHF)用于脑损伤后治疗的可行性和作用机制.方法12只健康犬随机分为2组:治疗组(6只),对照组(6只).采用改进的Feeney法自由落体致犬脑损伤,治疗组在伤后6小时后采用血液滤过治疗,血流量为90~100ml,置换液为500~800ml/h.持续监测生命体征,每2小时检测血气分析,乳酸和细胞因子:伤后24小时动物处死做脑水含量和组织学检查.结果研究期间,治疗组动物无死亡,犬肛温可在15~18分钟后下降并维持29~32℃之间;与对照组比较,血浆乳酸、IL-1 β、IL6、TNF-α水平显著低于对照组(P<0.05~0.01),脑组织含水量明显低于对照组.结论血液滤过可用于脑损伤后亚低温治疗;同时,血液滤过能较好地调节内环境、清除体内细胞因子和乳酸等炎性介质,这对减少脑组织的继发性损伤有益。" @default.
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- W3030626768 date "2004-09-15" @default.
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- W3030626768 title "Effect of Hemofiltration on Plasma Cytokines in Treatment of Canine Brain Injury" @default.
- W3030626768 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2004.18.002" @default.
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