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- W3030633265 abstract "Objective To investigate the effect of bradykinin (BK) on human lung cancer cell line A549 migration,invasion ability. Methods Scratch Healing and Transwell assay of bradykinin were used to detect scratch healing and movement on A549 human lung cancer cells. Analysis the changes of matrix metalloproteinase (MMP)-2, MMP-9 and E-Cadherin after stimulate and suppress 20 cases respectively in the aim to describe the mechanism by Western blotting. Results In the former, BK group promote cell migration significantly,migrated cell was 69.2±3.3, 94.1±2.9 respectively after 24 h and 48 h,blocking its receptor or ERK1/2 pathway inhibit migration,migrated cell was 51.2±2.1, 73.2±2.7 and 47.5±3.4,77.6±3.8 after 24 h and 48 h. In the latter,Transwell assay of A549 BK showed invasion of A549 BK can significantly promote the invasion ability of A549 to penetrate the basement membrane of the cell. And blocking BK receptor or ERK1/2 pathway can inhibit the invasion. Conclusion Bradykinin promote human lung adenocarcinoma cell line A549 migration and invasion.Key words: Bradykinin; Lung cancer cells; Migration; Invasion" @default.
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- W3030633265 date "2011-07-08" @default.
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- W3030633265 title "Effect of bradykinin on human lung cancer cell line A549 migration and invasion ability" @default.
- W3030633265 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2011.07.054" @default.
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