Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030635202> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W3030635202 endingPage "651" @default.
- W3030635202 startingPage "647" @default.
- W3030635202 abstract "ObjectiveTo investigate the expression levels of serum vasohibin-1(VASH-1)in type 2 diabetes mellitus(T2DM)patients at different stages of urinary albumin to creatinineratio(UACR)and to attempt to investigate the relationship between VASH-1 and inflammation and fibrosis in the pathogenesis of diabetic nephropathy(DN), one of the microvascular complications of T2DM.Methods486 patients with T2DMwere divided into four groups: normal albuminuria [UACR 300 mg/g, n=106], and clinical albuminuria hypertensive [UACR>300 mg/g, with hypertension, n=124] groups. Age, course, serum levels ofVASH1, inflammation markers(CRP, ESR)and fibrosis marker(TGF-β1)with other biochemical indicators were measured, and 130 normal control subjects were also included.ResultsCompared with normal control group, the levels of UACR, HbA1C, ESR, CRP, TGF-β1 and VASH-1 in groups ofnormal albuminuria, microalbuminuria, clinical albuminuria, and clinical albuminuria hypertensive were significantly higher(P<0.05). Pearson correlation analysis showed that levels of VASH-1 were positively correlated with UACR, HbA1C, ESR, CRPand TGF-β1(r=0.521, 0.261, 0.519, 0.523, 0.479, P<0.001), while multivariate regression analysis showed that levels of UACR, HbA1C, ESR, CRP and TGF-β1 were important factors affecting serum VASH-1 levels.ConclusionSerum levels of VASH-1 may become new biomarkers of early diagnosis of DN. Consequently, VASH-1 level may provide a new pattern and direction of inflammation and fibrosis for consideration in diabetic kidney damage. (Chin J Endocrinol Metab, 2016, 32: 647-651)Key words: Diabetic nephrophathy; Transforming growth factor--β1; Vasohibin-1" @default.
- W3030635202 created "2020-06-05" @default.
- W3030635202 creator A5024370089 @default.
- W3030635202 creator A5036555866 @default.
- W3030635202 creator A5040982304 @default.
- W3030635202 creator A5044920909 @default.
- W3030635202 creator A5070607706 @default.
- W3030635202 creator A5070951197 @default.
- W3030635202 date "2016-08-25" @default.
- W3030635202 modified "2023-09-26" @default.
- W3030635202 title "Expression levels of serum vasohibin-1 in type 2 diabetes mellitus patients with different excretion rates of urinary albumin and its clinical significance" @default.
- W3030635202 doi "https://doi.org/10.3760/cma.j.issn.1000-6699.2016.08.005" @default.
- W3030635202 hasPublicationYear "2016" @default.
- W3030635202 type Work @default.
- W3030635202 sameAs 3030635202 @default.
- W3030635202 citedByCount "0" @default.
- W3030635202 crossrefType "journal-article" @default.
- W3030635202 hasAuthorship W3030635202A5024370089 @default.
- W3030635202 hasAuthorship W3030635202A5036555866 @default.
- W3030635202 hasAuthorship W3030635202A5040982304 @default.
- W3030635202 hasAuthorship W3030635202A5044920909 @default.
- W3030635202 hasAuthorship W3030635202A5070607706 @default.
- W3030635202 hasAuthorship W3030635202A5070951197 @default.
- W3030635202 hasConcept C10146269 @default.
- W3030635202 hasConcept C126322002 @default.
- W3030635202 hasConcept C134018914 @default.
- W3030635202 hasConcept C2776174234 @default.
- W3030635202 hasConcept C2779922275 @default.
- W3030635202 hasConcept C2780559512 @default.
- W3030635202 hasConcept C2781203188 @default.
- W3030635202 hasConcept C2910068830 @default.
- W3030635202 hasConcept C555293320 @default.
- W3030635202 hasConcept C71924100 @default.
- W3030635202 hasConcept C77411442 @default.
- W3030635202 hasConcept C90924648 @default.
- W3030635202 hasConceptScore W3030635202C10146269 @default.
- W3030635202 hasConceptScore W3030635202C126322002 @default.
- W3030635202 hasConceptScore W3030635202C134018914 @default.
- W3030635202 hasConceptScore W3030635202C2776174234 @default.
- W3030635202 hasConceptScore W3030635202C2779922275 @default.
- W3030635202 hasConceptScore W3030635202C2780559512 @default.
- W3030635202 hasConceptScore W3030635202C2781203188 @default.
- W3030635202 hasConceptScore W3030635202C2910068830 @default.
- W3030635202 hasConceptScore W3030635202C555293320 @default.
- W3030635202 hasConceptScore W3030635202C71924100 @default.
- W3030635202 hasConceptScore W3030635202C77411442 @default.
- W3030635202 hasConceptScore W3030635202C90924648 @default.
- W3030635202 hasIssue "11" @default.
- W3030635202 hasLocation W30306352021 @default.
- W3030635202 hasOpenAccess W3030635202 @default.
- W3030635202 hasPrimaryLocation W30306352021 @default.
- W3030635202 hasRelatedWork W1966775855 @default.
- W3030635202 hasRelatedWork W2091567622 @default.
- W3030635202 hasRelatedWork W2131401857 @default.
- W3030635202 hasRelatedWork W2275692552 @default.
- W3030635202 hasRelatedWork W2352829872 @default.
- W3030635202 hasRelatedWork W2372174690 @default.
- W3030635202 hasRelatedWork W2375770576 @default.
- W3030635202 hasRelatedWork W2385372586 @default.
- W3030635202 hasRelatedWork W2386041092 @default.
- W3030635202 hasRelatedWork W2386621501 @default.
- W3030635202 hasRelatedWork W2387449113 @default.
- W3030635202 hasRelatedWork W2392932807 @default.
- W3030635202 hasRelatedWork W2580425188 @default.
- W3030635202 hasRelatedWork W2756177955 @default.
- W3030635202 hasRelatedWork W2947151344 @default.
- W3030635202 hasRelatedWork W2953025659 @default.
- W3030635202 hasRelatedWork W2981434436 @default.
- W3030635202 hasRelatedWork W3030580227 @default.
- W3030635202 hasRelatedWork W3031986589 @default.
- W3030635202 hasRelatedWork W3120414278 @default.
- W3030635202 hasVolume "32" @default.
- W3030635202 isParatext "false" @default.
- W3030635202 isRetracted "false" @default.
- W3030635202 magId "3030635202" @default.
- W3030635202 workType "article" @default.