FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030639813> ?p ?o ?g. }

• W3030639813 endingPage "178" @default.
• W3030639813 startingPage "171" @default.
• W3030639813 abstract "Localized brain hypothermia (HYPO) can be achieved by infusing cold saline into the carotid artery of animals and patients. Studies suggest that HYPO improves behavioral and histological outcomes in focal ischemia models. Given that ischemic stroke and intracerebral hemorrhage (ICH) share pathophysiological overlap, we tested whether cold saline infusion is safe and neuroprotective when given during collagenase-induced ICH. Eighty-five adult male Sprague-Dawley rats were used. Experiment 1 investigated brain and body temperature changes associated with a cold saline infusion paradigm that was scaled from patients according to brain weight and blood volume (3 mL/20-minute infusion). Experiment 2 determined whether HYPO aggravated bleeding volume. Experiment 3 investigated if cerebral edema or elemental concentrations were altered by HYPO. We also collected core body temperature and activity data through telemetry. Experiment 4 investigated whether behavioral outcomes (e.g., skilled reaching) and tissue loss were influenced by HYPO. Our HYPO protocol decreased the ipsilateral striatal temperature by ∼0.20°C (p < 0.001), with no other effects. HYPO did not affect hematoma volume (p = 0.64), cerebral edema (p = 0.34), or elemental concentrations (p = 0.49) at 24 hours post-ICH. Although ICH caused persistent behavioral impairments, HYPO did not improve behavioral outcomes (measured by a neurological deficit scale, cylinder, and the staircase test; p > 0.05 for all). Brain tissue loss was not different between groups on day 28 post-ICH (p = 0.90). Although cold saline infusion appears to be safe in the acute post-ICH period, there was no evidence that this therapy improved outcome. However, our treatment protocol was relatively mild and additional interventions might help improve efficacy. Finally, our findings may also speak to the safety of this cooling approach in focal ischemia where hemorrhagic transformation is a risk; future studies on this issue are needed." @default.
• W3030639813 created "2020-06-05" @default.
• W3030639813 creator A5020373936 @default.
• W3030639813 creator A5025345280 @default.
• W3030639813 creator A5039432888 @default.
• W3030639813 creator A5042742576 @default.
• W3030639813 creator A5059406679 @default.
• W3030639813 creator A5060268592 @default.
• W3030639813 date "2020-09-01" @default.
• W3030639813 modified "2023-09-28" @default.
• W3030639813 title "Infusion of Cold Saline into the Carotid Artery Does Not Affect Outcome After Intrastriatal Hemorrhage" @default.
• W3030639813 cites W1126117231 @default.
• W3030639813 cites W1581567111 @default.
• W3030639813 cites W1973352521 @default.
• W3030639813 cites W2011096901 @default.
• W3030639813 cites W2018409191 @default.
• W3030639813 cites W2027495932 @default.
• W3030639813 cites W2029011122 @default.
• W3030639813 cites W2035018608 @default.
• W3030639813 cites W2035193541 @default.
• W3030639813 cites W2065723600 @default.
• W3030639813 cites W2072314313 @default.
• W3030639813 cites W2073525006 @default.
• W3030639813 cites W2083794026 @default.
• W3030639813 cites W2087841807 @default.
• W3030639813 cites W2088339033 @default.
• W3030639813 cites W2092026036 @default.
• W3030639813 cites W2105196489 @default.
• W3030639813 cites W2114015652 @default.
• W3030639813 cites W2132862382 @default.
• W3030639813 cites W2140951756 @default.
• W3030639813 cites W2166034362 @default.
• W3030639813 cites W2198565839 @default.
• W3030639813 cites W2401831246 @default.
• W3030639813 cites W2488953036 @default.
• W3030639813 cites W2558497090 @default.
• W3030639813 cites W2583247392 @default.
• W3030639813 cites W2775863821 @default.
• W3030639813 cites W2808277102 @default.
• W3030639813 cites W2900823884 @default.
• W3030639813 cites W2909951994 @default.
• W3030639813 cites W2937750147 @default.
• W3030639813 cites W2986789828 @default.
• W3030639813 cites W2997429880 @default.
• W3030639813 cites W3171831654 @default.
• W3030639813 cites W4296816736 @default.
• W3030639813 doi "https://doi.org/10.1089/ther.2020.0010" @default.
• W3030639813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7482714" @default.
• W3030639813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32456561" @default.
• W3030639813 hasPublicationYear "2020" @default.
• W3030639813 type Work @default.
• W3030639813 sameAs 3030639813 @default.
• W3030639813 citedByCount "2" @default.
• W3030639813 countsByYear W30306398132021 @default.
• W3030639813 countsByYear W30306398132023 @default.
• W3030639813 crossrefType "journal-article" @default.
• W3030639813 hasAuthorship W3030639813A5020373936 @default.
• W3030639813 hasAuthorship W3030639813A5025345280 @default.
• W3030639813 hasAuthorship W3030639813A5039432888 @default.
• W3030639813 hasAuthorship W3030639813A5042742576 @default.
• W3030639813 hasAuthorship W3030639813A5059406679 @default.
• W3030639813 hasAuthorship W3030639813A5060268592 @default.
• W3030639813 hasBestOaLocation W30306398131 @default.
• W3030639813 hasConcept C10162356 @default.
• W3030639813 hasConcept C126322002 @default.
• W3030639813 hasConcept C127413603 @default.
• W3030639813 hasConcept C25498285 @default.
• W3030639813 hasConcept C2777094939 @default.
• W3030639813 hasConcept C2777390192 @default.
• W3030639813 hasConcept C2777397205 @default.
• W3030639813 hasConcept C2777736543 @default.
• W3030639813 hasConcept C2780645631 @default.
• W3030639813 hasConcept C2780886150 @default.
• W3030639813 hasConcept C42219234 @default.
• W3030639813 hasConcept C541997718 @default.
• W3030639813 hasConcept C71924100 @default.
• W3030639813 hasConcept C78519656 @default.
• W3030639813 hasConceptScore W3030639813C10162356 @default.
• W3030639813 hasConceptScore W3030639813C126322002 @default.
• W3030639813 hasConceptScore W3030639813C127413603 @default.
• W3030639813 hasConceptScore W3030639813C25498285 @default.
• W3030639813 hasConceptScore W3030639813C2777094939 @default.
• W3030639813 hasConceptScore W3030639813C2777390192 @default.
• W3030639813 hasConceptScore W3030639813C2777397205 @default.
• W3030639813 hasConceptScore W3030639813C2777736543 @default.
• W3030639813 hasConceptScore W3030639813C2780645631 @default.
• W3030639813 hasConceptScore W3030639813C2780886150 @default.
• W3030639813 hasConceptScore W3030639813C42219234 @default.
• W3030639813 hasConceptScore W3030639813C541997718 @default.
• W3030639813 hasConceptScore W3030639813C71924100 @default.
• W3030639813 hasConceptScore W3030639813C78519656 @default.
• W3030639813 hasIssue "3" @default.
• W3030639813 hasLocation W30306398131 @default.
• W3030639813 hasLocation W30306398132 @default.
• W3030639813 hasLocation W30306398133 @default.
• W3030639813 hasOpenAccess W3030639813 @default.
• W3030639813 hasPrimaryLocation W30306398131 @default.
• W3030639813 hasRelatedWork W1980651541 @default.

• next