Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030645152> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3030645152 endingPage "689" @default.
- W3030645152 startingPage "684" @default.
- W3030645152 abstract "ObjectiveTo investigate the survival of patients with osteosarcoma treated in a single institute.MethodsA total of 44 patients with osteosarcoma who had undergone surgical treatment in the Second Hospital of Shanxi Medical University from January 2013 to January 2018 were enrolled in this retrospective study. After the diagnosis of osteosarcoma, patients received cisplatin plus doxorubicin neoadjuvant chemotherapy. The patient's basic data, auxiliary examination results, surgical methods, pathological reports, prognosis and other information were reviewed and recorded, and the Kaplan-Meier method, Cox regression model were used to analyze the relationship between various factors and prognosis of patients.ResultsAmong 44 patients, there were 23 males and 21 females, aged from 7 to 62 years old (average 27.2 years old); the tumor site of 5 cases was located at the upper limbs and 39 was located at the lower limbs; the diameter of the tumor was < 10 cm in 30 cases, ≥10 cm in 14 cases. All patients underwent extensive resection, including 35 cases of limb salvage surgery and 9 cases of amputation. At the end of follow-up, the 3-year overall survival rate was 65.5%. The 3-year overall survival rates in patients with or without local recurrence were 40.0% and 72.4%, respectively (P = 0.037). The 3-year overall survival rates in patients with or without lung metastasis were 32.0% and 84.5%, respectively (P < 0.01). The 3-year overall survival rates in patients with tumor's diameter≥10 cm or <10 cm were 40.2% and 78.1%, respectively (P = 0.003). The 3-year overall survival rates in patients with or without standard chemotherapy were 74.9% and 35.8%, respectively (P = 0.048). The 3-year overall survival rates in patients with high or normal lactate dehydrogenase at the time of diagnosis were 38.1% and 72.3%, respectively (P = 0.010). Multivariate analysis showed that standard chemotherapy (P = 0.005) and lung metastasis (P = 0.003) were independent prognostic factors affecting the survival of patients with osteosarcoma.ConclusionsNeoadjuvant chemotherapy combined with surgical methods can improve the survival rate of patients with osteosarcoma of the extremities. Nonstandard chemotherapy and lung metastasis during or after treatment affect the survival of patients with osteosarcoma.Key words: Osteosarcoma; Chemotherapy, adjuvant; Prognosis; Neoplasm metastasis" @default.
- W3030645152 created "2020-06-05" @default.
- W3030645152 creator A5006715667 @default.
- W3030645152 creator A5067160607 @default.
- W3030645152 creator A5083113567 @default.
- W3030645152 date "2019-10-28" @default.
- W3030645152 modified "2023-09-24" @default.
- W3030645152 title "Prognosis analysis of 44 patients with extremity osteosarcoma" @default.
- W3030645152 doi "https://doi.org/10.3760/cma.j.issn.1006-9801.2019.10.009" @default.
- W3030645152 hasPublicationYear "2019" @default.
- W3030645152 type Work @default.
- W3030645152 sameAs 3030645152 @default.
- W3030645152 citedByCount "0" @default.
- W3030645152 crossrefType "journal-article" @default.
- W3030645152 hasAuthorship W3030645152A5006715667 @default.
- W3030645152 hasAuthorship W3030645152A5067160607 @default.
- W3030645152 hasAuthorship W3030645152A5083113567 @default.
- W3030645152 hasConcept C121608353 @default.
- W3030645152 hasConcept C126322002 @default.
- W3030645152 hasConcept C141071460 @default.
- W3030645152 hasConcept C142724271 @default.
- W3030645152 hasConcept C167135981 @default.
- W3030645152 hasConcept C195910791 @default.
- W3030645152 hasConcept C207886595 @default.
- W3030645152 hasConcept C2776204877 @default.
- W3030645152 hasConcept C2776283816 @default.
- W3030645152 hasConcept C2776694085 @default.
- W3030645152 hasConcept C2777760704 @default.
- W3030645152 hasConcept C2779013556 @default.
- W3030645152 hasConcept C50382708 @default.
- W3030645152 hasConcept C71924100 @default.
- W3030645152 hasConceptScore W3030645152C121608353 @default.
- W3030645152 hasConceptScore W3030645152C126322002 @default.
- W3030645152 hasConceptScore W3030645152C141071460 @default.
- W3030645152 hasConceptScore W3030645152C142724271 @default.
- W3030645152 hasConceptScore W3030645152C167135981 @default.
- W3030645152 hasConceptScore W3030645152C195910791 @default.
- W3030645152 hasConceptScore W3030645152C207886595 @default.
- W3030645152 hasConceptScore W3030645152C2776204877 @default.
- W3030645152 hasConceptScore W3030645152C2776283816 @default.
- W3030645152 hasConceptScore W3030645152C2776694085 @default.
- W3030645152 hasConceptScore W3030645152C2777760704 @default.
- W3030645152 hasConceptScore W3030645152C2779013556 @default.
- W3030645152 hasConceptScore W3030645152C50382708 @default.
- W3030645152 hasConceptScore W3030645152C71924100 @default.
- W3030645152 hasIssue "10" @default.
- W3030645152 hasLocation W30306451521 @default.
- W3030645152 hasOpenAccess W3030645152 @default.
- W3030645152 hasPrimaryLocation W30306451521 @default.
- W3030645152 hasRelatedWork W178533258 @default.
- W3030645152 hasRelatedWork W2028979122 @default.
- W3030645152 hasRelatedWork W2031488054 @default.
- W3030645152 hasRelatedWork W2160011730 @default.
- W3030645152 hasRelatedWork W2214142774 @default.
- W3030645152 hasRelatedWork W2313015562 @default.
- W3030645152 hasRelatedWork W2355173569 @default.
- W3030645152 hasRelatedWork W2373384453 @default.
- W3030645152 hasRelatedWork W2379084420 @default.
- W3030645152 hasRelatedWork W2394073026 @default.
- W3030645152 hasRelatedWork W2417768868 @default.
- W3030645152 hasRelatedWork W2607274726 @default.
- W3030645152 hasRelatedWork W2940640561 @default.
- W3030645152 hasRelatedWork W2947119734 @default.
- W3030645152 hasRelatedWork W2998085994 @default.
- W3030645152 hasRelatedWork W3024430199 @default.
- W3030645152 hasRelatedWork W3030323397 @default.
- W3030645152 hasRelatedWork W3030537253 @default.
- W3030645152 hasRelatedWork W1798345456 @default.
- W3030645152 hasRelatedWork W2339628614 @default.
- W3030645152 hasVolume "31" @default.
- W3030645152 isParatext "false" @default.
- W3030645152 isRetracted "false" @default.
- W3030645152 magId "3030645152" @default.
- W3030645152 workType "article" @default.