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- W3030651728 abstract "目的 观察嗅球摘除昆明小鼠自主活动和探究活动的改变,及皮质杏仁核和前额叶皮层5-羟色胺(5-HT)的表达,了解嗅球与学习和动机等高级生理活动的关系及可能机制,分析嗅球摘除昆明小鼠模拟阿尔茨海默病(AD)特征行为的可行性.方法 制备嗅球摘除昆明小鼠模型,采用小鼠自主活动实验和小鼠洞板实验观察其学习记忆活动和动机活动;应用免疫组织化学方法观察皮层、皮质杏仁核5-HT的表达.结果 嗅球摘除昆明小鼠术后14d出现探究活动较对照组减少[分别为(7.22±3.60)次,(24.71±14.11)次,P＜0.01],自主活动较对照组增加[分别为(182.15±42.91)次,(122.53±19.65)次,P＜0.01];嗅球摘除14 d小鼠皮质杏仁核5-HT的表达较假手术组明显增强,图像分析皮质杏仁核5-HT阳性神经元平均光密度值增加[分别为(0.149±0.025),(0.107±0.013),P＜0.01)];前额叶皮质的5-HT较假手术组小鼠减少,5-HT阳性神经元平均光密度值减少[分别为(0.068±0.060),(0.126±0.017),P＜0.01)].结论 嗅球摘除昆明小鼠探究活动减弱,自主活动增加,可能与皮质杏仁核5-HT能神经元增加、前额叶皮质的5-HT能神经元减少有关,与老年性痴呆患者的精神改变及生化机制相似。" @default.
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- W3030651728 date "2008-01-20" @default.
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- W3030651728 title "Effects of olfactory bulbectomy on mouse locomotive activity and motivational behavior of KM mice and serotonergic neurons of frontal cortex and cortical amygdaloid nucleus" @default.
- W3030651728 doi "https://doi.org/10.3760/cma.j.issn.1005-8559.2008.01.002" @default.
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