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- W3030658409 abstract "Objective To investigate the clinical value of the combined detection of the serum tumor marker(including CA15-3,CYFRA21-1,TSGF and CA19-9) in the diagnosis and treatment of breast cancer.Methods The serum samples of 182 patients with breast cancer were collected,and tumor markers CA15-3,CYFRA21-1,TSGF and CA19-9 were detected with electrochemiluminescence method,and TSGF was detected with chemocolorimetry method.The results were compared with 80 cases of benign breast disease and 50 normal cases.Results The serum levels of CA15-3,TSGF,OPN and CA125 of breast cancer patients were significantly higher than those of the benign breast disease and the normal cases (P ＜ 0.01 ).The sensitivity of CA15-3 to breast cancer was 60.4％ ( 110/182),with a specificity of 90.0％ (45/50),the sensitivity of CYFRA21-1 was 72.5 ( 132/182 ),with a specificity of 86.0％ (43/50),the sensitivity of TSGF was 74.7％ ( 136/182 )with a specificity of 92.0％ (46/50),and the sensitivity of CA19-9 was 36.3％ (66/182),with a specificity of 84.0％ (42/50).The sensitivity of the combination detection of above tumor markers was 91.8％ ( 167/182 ),with a specificity of 84.0％ (42/50).Conclusions CA15-3,CYFRA21-1,TSGF and CA19-9 have certain diagnostic value in breast cancer complementarily,and the combined detection can significantly improve the sensitivity and accuracy of breast cancer diagnosis.Key words: Breast cancer; Serum tumor marker; Combined detection; Value" @default.
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- W3030658409 date "2012-08-25" @default.
- W3030658409 modified "2023-10-01" @default.
- W3030658409 title "Clinical value of combined detection of the serum tumor marker in the diagnosis of breast cancer" @default.
- W3030658409 doi "https://doi.org/10.3760/cma.j.issn.1674-4756.2012.16.010" @default.
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