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- W3030658601 abstract "目的 研究健康人及精神分裂症患者外周血白细胞基因表达谱,分析精神分裂症患者基因表达水平的变化.方法取6例精神分裂症患者和6名健康人的外周血白细胞,提取总RNA,在反转录cDNA时,分别用Cy3、Cy5两种激发波长荧光标记,获得两组样本cDNA探针.将两组探针混合后与含8 464条人类基因表达谱芯片杂交,扫描、分析杂交结果.结果当Cy5与Cy3比值大于2或小于0.5时,在6对样本7次试验中有13条基因在精神分裂症患者中均下调表达.当Cy5与Cy3 比值大于1.5或小于0.7时,在6对样本7次试验共同出现差异的基因有31条,其中2条基因在精神分裂症患者中上调表达,29条下调表达.结论精神分裂症患者的一些基因表达水平与正常人存在差异,这些基因主要与免疫、神经细胞发育、神经传递、髓鞘形成有关。" @default.
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- W3030658601 date "2004-02-05" @default.
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- W3030658601 title "Microarray analysis of altered gene expression in schizophrenia" @default.
- W3030658601 doi "https://doi.org/10.3760/j:issn:1006-7884.2004.01.002" @default.
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