Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030658906> ?p ?o ?g. }
- W3030658906 endingPage "2292" @default.
- W3030658906 startingPage "2279" @default.
- W3030658906 abstract "Abstract Patients with metastatic breast cancer (MBC) have limited therapeutic options and novel treatments are critically needed. Prior research implicates tumor‐induced mobilization of myeloid cell populations in metastatic progression, as well as being an unfavorable outcome in MBC; however, the underlying mechanisms for these relationships remain unknown. Here, we provide evidence for a novel mechanism by which p38 promotes metastasis. Using triple‐negative breast cancer models, we showed that a selective inhibitor of p38 (p38i) significantly reduced tumor growth, angiogenesis, and lung metastasis. Importantly, p38i decreased the accumulation of myeloid populations, namely, myeloid‐derived suppressor cells (MDSCs) and CD163 + tumor‐associated macrophages (TAMs). p38 controlled the expression of tumor‐derived chemokines/cytokines that facilitated the recruitment of protumor myeloid populations. Depletion of MDSCs was accompanied by reduced TAM infiltration and phenocopied the antimetastatic effects of p38i. Reciprocally, p38i increased tumor infiltration by cytotoxic CD8 + T cells. Furthermore, the CD163 + /CD8 + expression ratio inversely correlated with metastasis‐free survival in breast cancer, suggesting that targeting p38 may improve clinical outcomes. Overall, our study highlights a previously unknown p38‐driven pathway as a therapeutic target in MBC." @default.
- W3030658906 created "2020-06-05" @default.
- W3030658906 creator A5001422785 @default.
- W3030658906 creator A5017152694 @default.
- W3030658906 creator A5051996888 @default.
- W3030658906 creator A5058401562 @default.
- W3030658906 creator A5063636785 @default.
- W3030658906 creator A5064055667 @default.
- W3030658906 creator A5065404552 @default.
- W3030658906 date "2020-05-28" @default.
- W3030658906 modified "2023-10-10" @default.
- W3030658906 title "Blockade of p38 kinase impedes the mobilization of protumorigenic myeloid populations to impact breast cancer metastasis" @default.
- W3030658906 cites W1494453913 @default.
- W3030658906 cites W1637979534 @default.
- W3030658906 cites W1669428397 @default.
- W3030658906 cites W1919137762 @default.
- W3030658906 cites W1925817305 @default.
- W3030658906 cites W1930083400 @default.
- W3030658906 cites W1950981769 @default.
- W3030658906 cites W1963904011 @default.
- W3030658906 cites W1978651414 @default.
- W3030658906 cites W1993175385 @default.
- W3030658906 cites W1995481385 @default.
- W3030658906 cites W2003661931 @default.
- W3030658906 cites W2004298865 @default.
- W3030658906 cites W2017322644 @default.
- W3030658906 cites W2019209583 @default.
- W3030658906 cites W2023075736 @default.
- W3030658906 cites W2028792865 @default.
- W3030658906 cites W2040048742 @default.
- W3030658906 cites W2045158051 @default.
- W3030658906 cites W2059803720 @default.
- W3030658906 cites W2064315259 @default.
- W3030658906 cites W2072212283 @default.
- W3030658906 cites W2074189563 @default.
- W3030658906 cites W2075894019 @default.
- W3030658906 cites W2077945837 @default.
- W3030658906 cites W2084472730 @default.
- W3030658906 cites W2085934079 @default.
- W3030658906 cites W2112436968 @default.
- W3030658906 cites W2116522697 @default.
- W3030658906 cites W2121507786 @default.
- W3030658906 cites W2124969084 @default.
- W3030658906 cites W2132719717 @default.
- W3030658906 cites W2135137305 @default.
- W3030658906 cites W2154453972 @default.
- W3030658906 cites W2159576923 @default.
- W3030658906 cites W2165064029 @default.
- W3030658906 cites W2169509228 @default.
- W3030658906 cites W2170368666 @default.
- W3030658906 cites W2177185177 @default.
- W3030658906 cites W2308070604 @default.
- W3030658906 cites W2319962899 @default.
- W3030658906 cites W2471500324 @default.
- W3030658906 cites W2560292102 @default.
- W3030658906 cites W2564154830 @default.
- W3030658906 cites W2594679090 @default.
- W3030658906 cites W2596133050 @default.
- W3030658906 cites W2600317738 @default.
- W3030658906 cites W2604805073 @default.
- W3030658906 cites W2612857912 @default.
- W3030658906 cites W2662801289 @default.
- W3030658906 cites W2728571926 @default.
- W3030658906 cites W2769869838 @default.
- W3030658906 cites W2781525129 @default.
- W3030658906 cites W2801309958 @default.
- W3030658906 cites W2803199141 @default.
- W3030658906 cites W2803985368 @default.
- W3030658906 cites W2853606589 @default.
- W3030658906 cites W2893870376 @default.
- W3030658906 cites W4229714030 @default.
- W3030658906 doi "https://doi.org/10.1002/ijc.33050" @default.
- W3030658906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7484223" @default.
- W3030658906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32452014" @default.
- W3030658906 hasPublicationYear "2020" @default.
- W3030658906 type Work @default.
- W3030658906 sameAs 3030658906 @default.
- W3030658906 citedByCount "10" @default.
- W3030658906 countsByYear W30306589062021 @default.
- W3030658906 countsByYear W30306589062022 @default.
- W3030658906 countsByYear W30306589062023 @default.
- W3030658906 crossrefType "journal-article" @default.
- W3030658906 hasAuthorship W3030658906A5001422785 @default.
- W3030658906 hasAuthorship W3030658906A5017152694 @default.
- W3030658906 hasAuthorship W3030658906A5051996888 @default.
- W3030658906 hasAuthorship W3030658906A5058401562 @default.
- W3030658906 hasAuthorship W3030658906A5063636785 @default.
- W3030658906 hasAuthorship W3030658906A5064055667 @default.
- W3030658906 hasAuthorship W3030658906A5065404552 @default.
- W3030658906 hasBestOaLocation W30306589061 @default.
- W3030658906 hasConcept C121608353 @default.
- W3030658906 hasConcept C126322002 @default.
- W3030658906 hasConcept C13373296 @default.
- W3030658906 hasConcept C154317977 @default.
- W3030658906 hasConcept C167672396 @default.
- W3030658906 hasConcept C179185449 @default.
- W3030658906 hasConcept C201750760 @default.
- W3030658906 hasConcept C202751555 @default.