Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030671894> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3030671894 endingPage "1041" @default.
- W3030671894 startingPage "1037" @default.
- W3030671894 abstract "ObjectiveTo explore the value of GALAD model, including gender, age, AFP, AFP-L3 and DCP in diagnosis of primary hepatocellular carcinoma and prediction of microvascular invasion (MVI).MethodsUsing retrospective study method, 5 919 patients with primary hepatocellular carcinoma (HCC) who received radical operation from January 2015 to December 2018 in Eastern Hepatobiliary Surgery Hospital were enrolled into study group. At the same time, 1 745 patients with benign liver diseases (BLDs) were enrolled into control group. The concentration of DCP was detected by Lumipulse G1200 automatic immune analyzer, and the concentration of AFP was detected by Cobas e601 automatic immune analyzer. AFP-L3 was detected by affinity adsorption centrifugation. The non-parametric Mann Whitney test was used to compare the difference between two groups. The chi square test was used to compare the rates. The diagnostic value of single serological marker and GALAD model for primary hepatocellular carcinoma was analyzed. The predictive effect of GALAD model on MVI of primary hepatocellular carcinoma was evaluated.ResultsCompared with single serum marker, the diagnostic value of GALAD model is higher. When the cutoff value is -0.33, the diagnostic sensitivity, specificity and accuracy reach to 91.9% (5 440/5 919), 86.8% (1 515/1 745) and 90.7% (6 955/7 664), respectively. The area under the curve can reach 0.960 [95%CI (0.955-0.964)]. Compared with no MVI (MO) group, the value of GALAD model in MVI low-risk group (M1), MVI high-risk group (M2) and MVI (M1+2) were significantly higher (Z values were-12.517, -22.883, -21.655, P<0.05), Galad model predicts MVI (M2) in high risk group,AUC was 0.717 [95%CI (0.701-0.733)] (M0 ratio M2).ConclusionGALAD model has better diagnostic performance in primary hepatocellular carcinoma and has certain predictive value for microvascular invasion.Key words: Carcinoma, hepatocellular; Liver neoplasms; Neoplasm invasiveness; Microvessels; alpha-Fetoproteins; Prothrombin" @default.
- W3030671894 created "2020-06-05" @default.
- W3030671894 creator A5011776066 @default.
- W3030671894 creator A5031568476 @default.
- W3030671894 creator A5032561728 @default.
- W3030671894 creator A5040352781 @default.
- W3030671894 creator A5051764626 @default.
- W3030671894 creator A5060254639 @default.
- W3030671894 creator A5083896582 @default.
- W3030671894 creator A5088701616 @default.
- W3030671894 date "2019-12-11" @default.
- W3030671894 modified "2023-09-24" @default.
- W3030671894 title "Role of GALAD serological model in the clinical diagnosis of primary hepatocellular carcinoma" @default.
- W3030671894 doi "https://doi.org/10.3760/cma.j.issn.1009-9158.2019.12.012" @default.
- W3030671894 hasPublicationYear "2019" @default.
- W3030671894 type Work @default.
- W3030671894 sameAs 3030671894 @default.
- W3030671894 citedByCount "0" @default.
- W3030671894 crossrefType "journal-article" @default.
- W3030671894 hasAuthorship W3030671894A5011776066 @default.
- W3030671894 hasAuthorship W3030671894A5031568476 @default.
- W3030671894 hasAuthorship W3030671894A5032561728 @default.
- W3030671894 hasAuthorship W3030671894A5040352781 @default.
- W3030671894 hasAuthorship W3030671894A5051764626 @default.
- W3030671894 hasAuthorship W3030671894A5060254639 @default.
- W3030671894 hasAuthorship W3030671894A5083896582 @default.
- W3030671894 hasAuthorship W3030671894A5088701616 @default.
- W3030671894 hasConcept C121332964 @default.
- W3030671894 hasConcept C126322002 @default.
- W3030671894 hasConcept C12868164 @default.
- W3030671894 hasConcept C159654299 @default.
- W3030671894 hasConcept C203014093 @default.
- W3030671894 hasConcept C2777546739 @default.
- W3030671894 hasConcept C2778019345 @default.
- W3030671894 hasConcept C2778217198 @default.
- W3030671894 hasConcept C45189115 @default.
- W3030671894 hasConcept C58471807 @default.
- W3030671894 hasConcept C62520636 @default.
- W3030671894 hasConcept C71924100 @default.
- W3030671894 hasConcept C90924648 @default.
- W3030671894 hasConceptScore W3030671894C121332964 @default.
- W3030671894 hasConceptScore W3030671894C126322002 @default.
- W3030671894 hasConceptScore W3030671894C12868164 @default.
- W3030671894 hasConceptScore W3030671894C159654299 @default.
- W3030671894 hasConceptScore W3030671894C203014093 @default.
- W3030671894 hasConceptScore W3030671894C2777546739 @default.
- W3030671894 hasConceptScore W3030671894C2778019345 @default.
- W3030671894 hasConceptScore W3030671894C2778217198 @default.
- W3030671894 hasConceptScore W3030671894C45189115 @default.
- W3030671894 hasConceptScore W3030671894C58471807 @default.
- W3030671894 hasConceptScore W3030671894C62520636 @default.
- W3030671894 hasConceptScore W3030671894C71924100 @default.
- W3030671894 hasConceptScore W3030671894C90924648 @default.
- W3030671894 hasIssue "12" @default.
- W3030671894 hasLocation W30306718941 @default.
- W3030671894 hasOpenAccess W3030671894 @default.
- W3030671894 hasPrimaryLocation W30306718941 @default.
- W3030671894 hasRelatedWork W1965757989 @default.
- W3030671894 hasRelatedWork W1971389937 @default.
- W3030671894 hasRelatedWork W1972057857 @default.
- W3030671894 hasRelatedWork W2026721771 @default.
- W3030671894 hasRelatedWork W2039529710 @default.
- W3030671894 hasRelatedWork W2051924155 @default.
- W3030671894 hasRelatedWork W2135535264 @default.
- W3030671894 hasRelatedWork W2299212160 @default.
- W3030671894 hasRelatedWork W2327810008 @default.
- W3030671894 hasRelatedWork W2350086362 @default.
- W3030671894 hasRelatedWork W2352342905 @default.
- W3030671894 hasRelatedWork W2360245188 @default.
- W3030671894 hasRelatedWork W2376404665 @default.
- W3030671894 hasRelatedWork W2791166909 @default.
- W3030671894 hasRelatedWork W2807774998 @default.
- W3030671894 hasRelatedWork W2947902307 @default.
- W3030671894 hasRelatedWork W3030550139 @default.
- W3030671894 hasRelatedWork W3030716612 @default.
- W3030671894 hasRelatedWork W3177312516 @default.
- W3030671894 hasRelatedWork W863775208 @default.
- W3030671894 hasVolume "42" @default.
- W3030671894 isParatext "false" @default.
- W3030671894 isRetracted "false" @default.
- W3030671894 magId "3030671894" @default.
- W3030671894 workType "article" @default.