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- W3030702511 abstract "ObjectiveTo explore the clinical characteristics of the cognitive disorder in patients with small vessel disease (SVD).MethodsA total of 60 patients with SVD and 50 age, gender-matched healthy subjects were recruited consecutively from the Department of Neurology, Beijing Chaoyang Hospital.All the participants were performed by a battery of neuropsychological tests.The Fazekas scale was used to assess the severity of white matter lesions, and the scale of medial temporal lobe atrophy (MTA) was used to evaluate the severity of medial temporal lobe.ResultsPatients with SVD were associated with global cognitive function deficits, including the general tests of MMSE ((25.9±2.4) vs (28.1±1.7)) and MoCA ((23.0±3.7) vs (26.2±3.0)), and also with performances of AVLD-I((5.0±1.0) vs (8.2±2.0)), AVLT-D((3.7±1.0) vs (9.3±1.9)), AVLT-R((7.6±1.5) vs (11.7±1.6)), TMT-B, Stroop B, Stroop C and DST(P<0.05). The score of MOCA was related negatively with Fazekas scale (r=-0.361, P=0.04). The severity of Fazekas had a positive relationship with the scores of MTA (r=0.449, P=0.032).ConclusionPatients with SVD are closely correlated to general cognitive impairment, especially with memory decline, attention and executive function, which may be attributed to the impairment of frontal-subcortical circle.Key words: Small vessel disease; Cognition; Clinical characteristic" @default.
- W3030702511 created "2020-06-05" @default.
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- W3030702511 date "2018-01-20" @default.
- W3030702511 modified "2023-09-26" @default.
- W3030702511 title "The clinical characteristics of cognitive impairment in patients with small vessel disease" @default.
- W3030702511 doi "https://doi.org/10.3760/cma.j.issn.1674-6554.2018.01.008" @default.
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