FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030708385> ?p ?o ?g. }

• W3030708385 endingPage "461273" @default.
• W3030708385 startingPage "461273" @default.
• W3030708385 abstract "• Modified Gaussian models were applied to fit peaks of enantiomeric compounds • Restrictions were applied to control the baseline out of the peak region • Peak models allowed excellent fitting of isolated symmetric and asymmetric peaks • Deconvolution of peaks with moderate overlapping was also satisfactory • Approaches were applied to eight drugs analysed with several chiral columns The description of the profiles of chromatographic peaks has been studied extensively, with a large number of proposed mathematical functions. Among them, the accuracy achieved with modified Gaussian models that describe the deviation of an ideal Gaussian peak as a change in the peak variance or standard deviation over time, has been highlighted. These models are, in fact, a family of functions of different complexity with great flexibility to adjust chromatographic peaks over a wide range of asymmetries and shapes. However, an uncontrolled behaviour of the signal may occur outside the region being fitted, forcing the use of different strategies to overcome this problem. In this work, the performance of the LMG (Linear Modified Gaussian), PVMG (Parabolic Variance Modified Gaussian), and PLMG (Parabolic-Lorentzian Modified Gaussian) models is compared with variants obtained by combination of the modified Gaussian models with an equation that adds an exponential tail and with other functions that limit the growth of the independent variable. The behaviour of the approaches is checked through the simultaneous fitting of enantiomeric peaks showing a wide range of characteristics, obtained in the separation of drugs with chiral activity by liquid chromatography using enantioselective columns. The study is also carried out with the purpose of performing the deconvolution of the peaks of the enantiomers, when these are not completely resolved, in order to evaluate the enantiomeric fraction." @default.
• W3030708385 created "2020-06-05" @default.
• W3030708385 creator A5013147463 @default.
• W3030708385 creator A5016612619 @default.
• W3030708385 creator A5045928209 @default.
• W3030708385 creator A5070146407 @default.
• W3030708385 creator A5082223167 @default.
• W3030708385 date "2020-08-01" @default.
• W3030708385 modified "2023-10-16" @default.
• W3030708385 title "Modified Gaussian models applied to the description and deconvolution of peaks in chiral liquid chromatography" @default.
• W3030708385 cites W1971704874 @default.
• W3030708385 cites W1985432186 @default.
• W3030708385 cites W1987939257 @default.
• W3030708385 cites W1999810562 @default.
• W3030708385 cites W2001195021 @default.
• W3030708385 cites W2003524940 @default.
• W3030708385 cites W2005128028 @default.
• W3030708385 cites W2008087452 @default.
• W3030708385 cites W2016888205 @default.
• W3030708385 cites W2024676137 @default.
• W3030708385 cites W2045602490 @default.
• W3030708385 cites W2047236648 @default.
• W3030708385 cites W2047359961 @default.
• W3030708385 cites W2050237533 @default.
• W3030708385 cites W2053715888 @default.
• W3030708385 cites W2071225185 @default.
• W3030708385 cites W2087205864 @default.
• W3030708385 cites W2092165055 @default.
• W3030708385 cites W2314240921 @default.
• W3030708385 cites W2613509012 @default.
• W3030708385 cites W2826826432 @default.
• W3030708385 cites W2967329949 @default.
• W3030708385 doi "https://doi.org/10.1016/j.chroma.2020.461273" @default.
• W3030708385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32709325" @default.
• W3030708385 hasPublicationYear "2020" @default.
• W3030708385 type Work @default.
• W3030708385 sameAs 3030708385 @default.
• W3030708385 citedByCount "0" @default.
• W3030708385 crossrefType "journal-article" @default.
• W3030708385 hasAuthorship W3030708385A5013147463 @default.
• W3030708385 hasAuthorship W3030708385A5016612619 @default.
• W3030708385 hasAuthorship W3030708385A5045928209 @default.
• W3030708385 hasAuthorship W3030708385A5070146407 @default.
• W3030708385 hasAuthorship W3030708385A5082223167 @default.
• W3030708385 hasConcept C105795698 @default.
• W3030708385 hasConcept C11413529 @default.
• W3030708385 hasConcept C134306372 @default.
• W3030708385 hasConcept C147597530 @default.
• W3030708385 hasConcept C151376022 @default.
• W3030708385 hasConcept C159985019 @default.
• W3030708385 hasConcept C163716315 @default.
• W3030708385 hasConcept C166550679 @default.
• W3030708385 hasConcept C174576160 @default.
• W3030708385 hasConcept C185592680 @default.
• W3030708385 hasConcept C186060115 @default.
• W3030708385 hasConcept C192562407 @default.
• W3030708385 hasConcept C204323151 @default.
• W3030708385 hasConcept C22679943 @default.
• W3030708385 hasConcept C33923547 @default.
• W3030708385 hasConcept C43617362 @default.
• W3030708385 hasConcept C486523 @default.
• W3030708385 hasConcept C71240020 @default.
• W3030708385 hasConcept C7218915 @default.
• W3030708385 hasConcept C86803240 @default.
• W3030708385 hasConceptScore W3030708385C105795698 @default.
• W3030708385 hasConceptScore W3030708385C11413529 @default.
• W3030708385 hasConceptScore W3030708385C134306372 @default.
• W3030708385 hasConceptScore W3030708385C147597530 @default.
• W3030708385 hasConceptScore W3030708385C151376022 @default.
• W3030708385 hasConceptScore W3030708385C159985019 @default.
• W3030708385 hasConceptScore W3030708385C163716315 @default.
• W3030708385 hasConceptScore W3030708385C166550679 @default.
• W3030708385 hasConceptScore W3030708385C174576160 @default.
• W3030708385 hasConceptScore W3030708385C185592680 @default.
• W3030708385 hasConceptScore W3030708385C186060115 @default.
• W3030708385 hasConceptScore W3030708385C192562407 @default.
• W3030708385 hasConceptScore W3030708385C204323151 @default.
• W3030708385 hasConceptScore W3030708385C22679943 @default.
• W3030708385 hasConceptScore W3030708385C33923547 @default.
• W3030708385 hasConceptScore W3030708385C43617362 @default.
• W3030708385 hasConceptScore W3030708385C486523 @default.
• W3030708385 hasConceptScore W3030708385C71240020 @default.
• W3030708385 hasConceptScore W3030708385C7218915 @default.
• W3030708385 hasConceptScore W3030708385C86803240 @default.
• W3030708385 hasFunder F4320321837 @default.
• W3030708385 hasLocation W30307083851 @default.
• W3030708385 hasLocation W30307083852 @default.
• W3030708385 hasOpenAccess W3030708385 @default.
• W3030708385 hasPrimaryLocation W30307083851 @default.
• W3030708385 hasRelatedWork W1965413986 @default.
• W3030708385 hasRelatedWork W2005962786 @default.
• W3030708385 hasRelatedWork W2066238884 @default.
• W3030708385 hasRelatedWork W2073831843 @default.
• W3030708385 hasRelatedWork W2081895835 @default.
• W3030708385 hasRelatedWork W2087205864 @default.
• W3030708385 hasRelatedWork W2386389495 @default.
• W3030708385 hasRelatedWork W3030708385 @default.
• W3030708385 hasRelatedWork W3196632227 @default.

• next