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- W3030734172 abstract "Objective To define the boundary values of the S/CO (signal-to-cut-off) for screening hepatitis C antibody (anti-HCV) 95% true-positive samples by automatic chemiluminescence assay in Chinese population. Methods 202 anti-HCV-positive samples was screened out with automatic chemiluminescence instruments. S/CO values between 1-20 in the I7000 or 1-35 in the ECI were set as criteria in the study group. Anti-HCV serological results were confirmed by chiron recombinant immunoblot assay( RIBA ) and HCV 3.0 strip immunoblot assay (SIA). HCV RNA was tested. Receiver operating characteristic (ROC) curve was drawn and S/CO threshold was obtained by SPSS 13.0 software. Results Of 202 specimens of initial screening of anti-HCV-positive blood sera, 33 (16%) of them were confirmed negative when detected with RIBA and RNA test. In 92 (46%) RIBA positive samples HCV RNA was found positive in only 30 (33%)of them. All HCV RNA were negative in 77 (38%) indeterminate samples when tested with RIBA. If the indeterminate result tested with RIBA was not included in the statistics analysis, the positive coincidence rate of RIBA compared with I2000 and ECI was 83.2% and 75.2% respectively. When I2000 anti-HCV S/CO ratio was ≥3.4, and ECI anti-HCV S/CO was ≥ 9.1, the positive coincidence rate could achieve 95%. Conclusions In order to ensure 95% true positive ratio, it is the proposed that RIBA test or HCV RNA test should be used if possible, if the S/CO ratios range between 1.0-3.4 detected by the I2000 analyzer and 1.0-9.1 detected by the ECI analyzer.Key words: Hepatitis C antibodies; Immunoblotting; Chemiluminescent measurements; Evaluation studies" @default.
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- W3030734172 date "2009-09-11" @default.
- W3030734172 modified "2023-09-24" @default.
- W3030734172 title "Immunoblot analysis of hepatitis C antibody-weak positive samples detected by chemiluminescent assay" @default.
- W3030734172 doi "https://doi.org/10.3760/cma.j.issn.1009-9158.2009.09.005" @default.
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