FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030749868> ?p ?o ?g. }

• W3030749868 endingPage "E12" @default.
• W3030749868 startingPage "E12" @default.
• W3030749868 abstract "OBJECTIVE The authors sought to evaluate clinical and laboratory data from pituitary adenoma (PA) patients with functioning PA (associated with acromegaly [n = 10] or Cushing disease [n = 10]) or nonfunctioning PA (NFPA; n = 10) that were classified according to 2017 WHO criteria (based on the expression of the transcription factors pituitary-specific positive transcription factor 1 [Pit-1], a transcription factor member of the T-box family [Tpit], and steroidogenic factor 1 [SF-1]) and to assess the immunostaining results for growth hormone (GH) and adrenocorticotropic hormone (ACTH) in the corresponding tumors. METHODS Clinical and laboratory data were collected retrospectively. The percentage of tumoral cells positive for Pit-1, Tpit, or SF-1 was assessed and ImageJ software was used to evaluate immunopositivity in PAs with 2 different antibodies against GH (primary antibody 1 [AbGH-1] and primary antibody 2 [AbGH-2]) and 2 different antibodies against ACTH (primary antibody 1 [AbACTH-1] and primary antibody 2 [AbACTH-2]). RESULTS Cells with positive Pit-1 staining were more frequently observed in lesions from patients with acromegaly (acromegaly group) than in lesions from patients with Cushing disease (Cushing group; p < 0.001) and those from patients with NFPA (NFPA group; p < 0.001). The percentage of Tpit-positive cells was higher in the Cushing group than in the acromegaly (p < 0.001) and NFPA (p < 0.001) groups. No difference was detected regarding SF-1 frequency among all groups (p = 0.855). In acromegalic individuals, GH immunostaining levels varied depending on the antibody employed, and only one of the antibodies (AbGH-2) yielded higher values in comparison with the values for NFPA patients (p < 0.001). For all of the antibodies employed, no significant correlations were detected between GH tissue expression and the laboratory data (serum GH vs AbGH-1, p = 0.933; serum GH vs AbGH-2, p = 0.853; serum insulin-like growth factor–1 [IGF-1] vs AbGH-1, p = 0.407; serum IGF-1 vs AbGH-2, p = 0.881). In the Cushing group data, both antibodies showed similar ACTH tissue expression, which was higher than that obtained in the NFPA group (p < 0.001). There were no significant associations between ACTH immunohistochemical findings and ACTH serum levels (serum ACTH vs AbACTH-1, p = 0.651; serum ACTH vs AbACTH-2, p = 0.987). However, ACTH immunostaining evaluated with AbACTH-1 showed a significant correlation with 24-hour urinary cortisol (24-hour cortisol vs AbACTH-1, p = 0.047; 24-hour cortisol vs AbACTH-2, p = 0.071). CONCLUSIONS Immunostaining for Pit-1 and Tpit accurately identified lesions associated with acromegaly and Cushing disease, respectively. Conversely, SF-1 did not differentiate NFPA from lesions of the other two groups. Regarding hormonal tissue detection, results of the current investigation indicate that different antibodies may lead not only to divergent immunohistochemical results but also to lack of correlation with laboratory findings. Finally, PA classification based on transcription factor expression (Pit-1, Tpit, and SF-1), as proposed by the 2017 WHO classification of pituitary tumors, may avoid the limitations of PA classification based solely on digital immunohistochemical detection of hormones." @default.
• W3030749868 created "2020-06-05" @default.
• W3030749868 creator A5002043835 @default.
• W3030749868 creator A5010999360 @default.
• W3030749868 creator A5032032427 @default.
• W3030749868 creator A5043082983 @default.
• W3030749868 creator A5062511398 @default.
• W3030749868 creator A5091513761 @default.
• W3030749868 date "2020-06-01" @default.
• W3030749868 modified "2023-10-12" @default.
• W3030749868 title "Digital analysis of hormonal immunostaining in pituitary adenomas classified according to WHO 2017 criteria and correlation with preoperative laboratory findings" @default.
• W3030749868 cites W107039977 @default.
• W3030749868 cites W1484037037 @default.
• W3030749868 cites W1966091958 @default.
• W3030749868 cites W1970807450 @default.
• W3030749868 cites W1985678157 @default.
• W3030749868 cites W1993154503 @default.
• W3030749868 cites W2002595912 @default.
• W3030749868 cites W2004376390 @default.
• W3030749868 cites W2005771195 @default.
• W3030749868 cites W2008074001 @default.
• W3030749868 cites W2010277004 @default.
• W3030749868 cites W2017609319 @default.
• W3030749868 cites W2024596477 @default.
• W3030749868 cites W2026870745 @default.
• W3030749868 cites W2029724540 @default.
• W3030749868 cites W2030802344 @default.
• W3030749868 cites W2033422133 @default.
• W3030749868 cites W2038016263 @default.
• W3030749868 cites W2040411746 @default.
• W3030749868 cites W2054920456 @default.
• W3030749868 cites W2056163452 @default.
• W3030749868 cites W2080001542 @default.
• W3030749868 cites W2088265730 @default.
• W3030749868 cites W2120957388 @default.
• W3030749868 cites W2127400392 @default.
• W3030749868 cites W2132094049 @default.
• W3030749868 cites W2238072587 @default.
• W3030749868 cites W2431519461 @default.
• W3030749868 cites W2518302135 @default.
• W3030749868 cites W2535586443 @default.
• W3030749868 cites W2556661299 @default.
• W3030749868 cites W2586116929 @default.
• W3030749868 cites W2741425433 @default.
• W3030749868 cites W2787971552 @default.
• W3030749868 cites W2904667596 @default.
• W3030749868 cites W4234562118 @default.
• W3030749868 doi "https://doi.org/10.3171/2020.3.focus2039" @default.
• W3030749868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32480373" @default.
• W3030749868 hasPublicationYear "2020" @default.
• W3030749868 type Work @default.
• W3030749868 sameAs 3030749868 @default.
• W3030749868 citedByCount "2" @default.
• W3030749868 countsByYear W30307498682021 @default.
• W3030749868 countsByYear W30307498682023 @default.
• W3030749868 crossrefType "journal-article" @default.
• W3030749868 hasAuthorship W3030749868A5002043835 @default.
• W3030749868 hasAuthorship W3030749868A5010999360 @default.
• W3030749868 hasAuthorship W3030749868A5032032427 @default.
• W3030749868 hasAuthorship W3030749868A5043082983 @default.
• W3030749868 hasAuthorship W3030749868A5062511398 @default.
• W3030749868 hasAuthorship W3030749868A5091513761 @default.
• W3030749868 hasBestOaLocation W30307498681 @default.
• W3030749868 hasConcept C126322002 @default.
• W3030749868 hasConcept C134018914 @default.
• W3030749868 hasConcept C142724271 @default.
• W3030749868 hasConcept C159654299 @default.
• W3030749868 hasConcept C203014093 @default.
• W3030749868 hasConcept C204232928 @default.
• W3030749868 hasConcept C2776810848 @default.
• W3030749868 hasConcept C2777428134 @default.
• W3030749868 hasConcept C2777433750 @default.
• W3030749868 hasConcept C2779134260 @default.
• W3030749868 hasConcept C2779318953 @default.
• W3030749868 hasConcept C2984496839 @default.
• W3030749868 hasConcept C4224716 @default.
• W3030749868 hasConcept C71315377 @default.
• W3030749868 hasConcept C71924100 @default.
• W3030749868 hasConcept C90924648 @default.
• W3030749868 hasConceptScore W3030749868C126322002 @default.
• W3030749868 hasConceptScore W3030749868C134018914 @default.
• W3030749868 hasConceptScore W3030749868C142724271 @default.
• W3030749868 hasConceptScore W3030749868C159654299 @default.
• W3030749868 hasConceptScore W3030749868C203014093 @default.
• W3030749868 hasConceptScore W3030749868C204232928 @default.
• W3030749868 hasConceptScore W3030749868C2776810848 @default.
• W3030749868 hasConceptScore W3030749868C2777428134 @default.
• W3030749868 hasConceptScore W3030749868C2777433750 @default.
• W3030749868 hasConceptScore W3030749868C2779134260 @default.
• W3030749868 hasConceptScore W3030749868C2779318953 @default.
• W3030749868 hasConceptScore W3030749868C2984496839 @default.
• W3030749868 hasConceptScore W3030749868C4224716 @default.
• W3030749868 hasConceptScore W3030749868C71315377 @default.
• W3030749868 hasConceptScore W3030749868C71924100 @default.
• W3030749868 hasConceptScore W3030749868C90924648 @default.
• W3030749868 hasIssue "6" @default.
• W3030749868 hasLocation W30307498681 @default.
• W3030749868 hasOpenAccess W3030749868 @default.

• next