FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030754950> ?p ?o ?g. }

• W3030754950 endingPage "52" @default.
• W3030754950 startingPage "48" @default.
• W3030754950 abstract "ObjectiveTo investigate the effects of intrathecal injection (IT) of agonist and antagonist of N-methyl-D-aspartate receptor subunit 1 (NMDA NR1) on pain threshold and spinal levels of glutamate and glutamate transporter-1(GLT-1) in rat model of chronic constriction injury (CCI) induced neuropathic pain.MethodsSprague-Dawley (SD) rats were randomly divided into 4 groups (Sham, CCI, NMDA, and Humanin). The CCI model was established by right sciatic nerve constriction. The thermal and mechanical thresholds were assessed by paw withdrawal latency (PWL) to radiant heat and von Frey filaments at 1, 3, 5, 7, 10 and 14 days as well as behavior after CCI. The NMDA and Humanin groups were administered intrathecally for 3 days before surgery. Spinal expression of GLT-1 assessed by Weston blotting and levels of glutamate were measured by enzyme-linked immunosorbent assay (ELISA).ResultsCompared to Sham group, the rats in CCI group gradually appeared the symptoms of toe close together, foot valgus and repeated licking to the operative side of the hind legs after surgery, and the paw withdrawal thresh-old (PWT), and PWL were greatly decreased, reaching the lowest level on the 7th day. Meanwhile, the glutamate content was increased, and the GLT-1 expression was decreased in spinal cord (P<0.05). Compared to CCI group, the rats in NMDA group were observed with further decrease in PWT, PWL and GLT-1 expressions at all observed timepoints (P<0.05), but increase in glutamate content in spine cord (P<0.05). Compared to CCI group, the rats in Humanin group were observed with increase in PWT, PWL and GLT-1 expressions at all observed timepoint (P<0.05), but decrease in glutamate content in spine cord (P<0.05).ConclusionsNMDA receptor NR1 subunit participated in regulating neuropathic pain, inhibiting NMDA receptor NR1 subunit can alleviate neuropathic pain by down-regulating of glutamate and GLT-1.Key words: Receptors, N-methyl-D-aspartate/AG/AI/ME; Neuralgia/ME/DT; Glutamic acid/ME/DE; Spinal cord/ME" @default.
• W3030754950 created "2020-06-05" @default.
• W3030754950 creator A5005894447 @default.
• W3030754950 creator A5028653401 @default.
• W3030754950 date "2017-01-20" @default.
• W3030754950 modified "2023-09-26" @default.
• W3030754950 title "Mechanism and effects of NMDA receptor NR1 subunit on chronic constriction injury-induced neuropathic pain in a rat model" @default.
• W3030754950 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2017.01.014" @default.
• W3030754950 hasPublicationYear "2017" @default.
• W3030754950 type Work @default.
• W3030754950 sameAs 3030754950 @default.
• W3030754950 citedByCount "0" @default.
• W3030754950 crossrefType "journal-article" @default.
• W3030754950 hasAuthorship W3030754950A5005894447 @default.
• W3030754950 hasAuthorship W3030754950A5028653401 @default.
• W3030754950 hasConcept C118552586 @default.
• W3030754950 hasConcept C126322002 @default.
• W3030754950 hasConcept C134018914 @default.
• W3030754950 hasConcept C170493617 @default.
• W3030754950 hasConcept C2775991916 @default.
• W3030754950 hasConcept C2777107010 @default.
• W3030754950 hasConcept C2778938600 @default.
• W3030754950 hasConcept C2780775167 @default.
• W3030754950 hasConcept C2781149210 @default.
• W3030754950 hasConcept C42219234 @default.
• W3030754950 hasConcept C61174792 @default.
• W3030754950 hasConcept C67018056 @default.
• W3030754950 hasConcept C71924100 @default.
• W3030754950 hasConcept C98274493 @default.
• W3030754950 hasConceptScore W3030754950C118552586 @default.
• W3030754950 hasConceptScore W3030754950C126322002 @default.
• W3030754950 hasConceptScore W3030754950C134018914 @default.
• W3030754950 hasConceptScore W3030754950C170493617 @default.
• W3030754950 hasConceptScore W3030754950C2775991916 @default.
• W3030754950 hasConceptScore W3030754950C2777107010 @default.
• W3030754950 hasConceptScore W3030754950C2778938600 @default.
• W3030754950 hasConceptScore W3030754950C2780775167 @default.
• W3030754950 hasConceptScore W3030754950C2781149210 @default.
• W3030754950 hasConceptScore W3030754950C42219234 @default.
• W3030754950 hasConceptScore W3030754950C61174792 @default.
• W3030754950 hasConceptScore W3030754950C67018056 @default.
• W3030754950 hasConceptScore W3030754950C71924100 @default.
• W3030754950 hasConceptScore W3030754950C98274493 @default.
• W3030754950 hasIssue "1" @default.
• W3030754950 hasLocation W30307549501 @default.
• W3030754950 hasOpenAccess W3030754950 @default.
• W3030754950 hasPrimaryLocation W30307549501 @default.
• W3030754950 hasRelatedWork W1989804049 @default.
• W3030754950 hasRelatedWork W2009767642 @default.
• W3030754950 hasRelatedWork W2010774051 @default.
• W3030754950 hasRelatedWork W2067763109 @default.
• W3030754950 hasRelatedWork W2347733494 @default.
• W3030754950 hasRelatedWork W2352609475 @default.
• W3030754950 hasRelatedWork W2355554084 @default.
• W3030754950 hasRelatedWork W2363133605 @default.
• W3030754950 hasRelatedWork W2367869879 @default.
• W3030754950 hasRelatedWork W2381510140 @default.
• W3030754950 hasRelatedWork W2444507462 @default.
• W3030754950 hasRelatedWork W2755447892 @default.
• W3030754950 hasRelatedWork W2904530627 @default.
• W3030754950 hasRelatedWork W3029422596 @default.
• W3030754950 hasRelatedWork W3030284438 @default.
• W3030754950 hasRelatedWork W3030690349 @default.
• W3030754950 hasRelatedWork W3031438045 @default.
• W3030754950 hasRelatedWork W3032274626 @default.
• W3030754950 hasRelatedWork W3144225445 @default.
• W3030754950 hasRelatedWork W3151546738 @default.
• W3030754950 hasVolume "19" @default.
• W3030754950 isParatext "false" @default.
• W3030754950 isRetracted "false" @default.
• W3030754950 magId "3030754950" @default.
• W3030754950 workType "article" @default.