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- W3030773207 abstract "：Objective To assess thechange of the CD4~+ CD25~+ Treg after the transplant nephrectomy in recipients sufferingfrom chronic allograft nephropathy (CAN) with normal PRA level.Methods Thirty recipientssuffering from CAN,aged 20-55 years old,with norlTlal PRA level,were divided into twogroups:removal group (n=17) and preserving group(n=13).CD4~+ CD25~(high)/CD4~+,CTLA-4 andFoxp3 in peripheral blood were tested at two time ends:O month and 2 months after thetransplant nephrectomy operation.Results (1) Ratio of CD4~+ CD25~(high)/CD4~+ at the Othand 2nd month in the removal group was(1.47±0.19)%,(1.08±0.16)%,and that was(1.44±0.25)%and (1.77±0.24)%,at the same time in the preserving group (P 0.05).(3)Theexpression of Foxp3 was (79.77±1.59)% and (69.07±4.37)% in the removal group,and thatwas (79.56±1.75)% and (79.09±2.05)% in the preserving group.The expression rate of Foxp3at the 2nd month in the removal group was significantly lower than in the preserving group(P<0.01).Conclusion Remoral of the graft can reduce the ratio of CD4~+CD25~(high)/CD4~+ and the expression of Foxp3,suggesting that the removal of the renalgraft may inhibit the activity of CD4~+ CD25~+ Treg." @default.
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- W3030773207 date "2010-03-20" @default.
- W3030773207 modified "2023-09-23" @default.
- W3030773207 title "The change of CD4~+ CD25~+regulatory T cells after the transplant neplwedamy in human renal redipients with chronicallograft nephropathy" @default.
- W3030773207 doi "https://doi.org/10.3760/cma.j.issn.0254-1785.2010.03.012" @default.
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