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- W3030775013 abstract "目的验证应用高效色谱法测定盐酸氯胺酮皮肤通透性的可行性。方法选择小鼠背部皮肤制备离体渗透模型，采用Franz扩散池模拟盐酸氯胺酮的体外经皮渗透过程，通过高效液相色谱分析测定盐酸氯胺酮的含量并进行精密度、回收率、稳定性和重现性实验。结果盐酸氯胺酮在浓度为0.10～10.00 μg/mL范围内线性关系良好(R2＝0.9999)，精密度、回收率、稳定性和重现性各项实验的RSD<2%。结论高效液相色谱法能快速、准确地测定皮肤通透性试验中盐酸氯胺酮的血药浓度。" @default.
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- W3030775013 date "2019-02-15" @default.
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- W3030775013 title "Detection of ketamine hydrochloride transdermal performance by HPLC" @default.
- W3030775013 doi "https://doi.org/10.3760/cma.j.issn.1008-6706.2019.04.027" @default.
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