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- W3030776989 abstract "To evaluate the efficacy and safety of liraglutide and neutral protamine hagedorn (NPH) in combination with metformin in newly diagnosed type 2 diabetic patients with continuous glucose monitoring system (CGMS). A total of 63 newly diagnosed type 2 diabetic patients were randomized into the liraglutide plus metformin group and NPH plus metformin group. They were treated for 12 weeks. Continuous glucose monitoring (CGM) was performed for 72 hours in both groups before and after treatment. The parameters of blood glucose fluctuations, blood lipid and BMI were measured and compared before and after treatment. Fasting plasma glucose (FBG), glycated hemoglobin A1c (HbA1c) and mean blood glucose (MBG) were decreased in both groups after 12 weeks, treatment, but there was no statistical difference in the comparison between the two groups (P>O.05). In the liraglutide group, the mean average glucose excursions (MAGE), large amplitude of glycemia excursion (LAGE), mean of daily differences (MODD), mean postprandial glucose excursion (MPPGE), TPG≤3.0 mmol/L, body mass index (BMI), triglyceride (TG), total cholesterol (TC), low density lipoprotein- cholesterol (LDL- C) and systolic blood pressure (SBP) were significantly lower than those in the NPH group respectively(t=2.773,3.250,2.870,2.721,4.955,2.686,2.152, 2.310,2.342,2.048, P<0.05, respectively). The incidence of hypoglycemia episode in the liraglutide group was significantly lower than in the NPH group (χ2=4.14, P<0.05). Both groups have a good control of blood glucose for newly diagnosed type 2 diabetic patients. As compared with NPH, liraglutide can reduce the glucose fluctuation and have less hypoglycemia event, while liraglutide is superior in weight reduction, improvement of blood lipid and blood pressure.Key words: Diabetes mellitus, type 2; Continuous glucose monitoring; Liraglutide; Glucose fluctuation" @default.
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- W3030776989 date "2014-12-27" @default.
- W3030776989 modified "2023-09-23" @default.
- W3030776989 title "Evaluation of efficacy and safety of liraglutide in newly diagnosed type 2 diabetic patients with continuous glucose monitoring system" @default.
- W3030776989 doi "https://doi.org/10.3760/cma.j.issn.1674-5809.2014.12.011" @default.
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