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- W3030804970 abstract "目的 研究SynaptotagminⅡ(简称Syt2)在RBL-2H3(简称RBL)胞吐中的作用.方法利用钙离子载体和抗原分别刺激Syt2+和Syt2-(分别为Syt2过表达和表达减弱的RBL),诱导其活化而分泌,检测分泌的β-氨基已糖苷酶、组织蛋白酶D和5-羟色胺,分析Syt2对于细胞分泌的影响.结果与对照相比,Syt2+分泌的β-氨基已糖苷酶无明显区别,而Syt2-分泌的β-氨基已糖苷酶增加达3.5倍,结果说明Syt2的过表达对β-氨基已糖苷酶分泌无影响,而Syt2表达减弱却促进β-氨基已糖苷酶的分泌.与对照相比,Syt2+分泌的组织蛋白酶D减少近一半,而Syt2-分泌的组织蛋白酶D增加近1倍,说明Syt2的表达量与组织蛋白酶D分泌量成负相关关系.与对照相比,Syt2+分泌的5-羟色胺无明显差别,而Syt2- 分泌的5-羟色胺有少量增加,说明Syt2的表达量对于5-羟色胺分泌有轻微影响.结论Syt2主要对于RBL溶酶体胞吐起负调控作用。" @default.
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- W3030804970 date "2005-07-21" @default.
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- W3030804970 title "The regulation ofsynaptotagmin II during exocytosis of RBL-2H3" @default.
- W3030804970 doi "https://doi.org/10.3760/j:issn:1009-9158.2005.07.017" @default.
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