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- W3030817811 abstract "目的：探讨原发性肺癌中bcl-2．Bax和p53mRNA表达水平及其与临床病理特征的关系。方法：用免疫组织化学Dako EnvisionTM二步法、反转录聚合酶链反应(RT-PCR)方法分别检测52例肺癌组织中bcl-2、bax、p53mRNA表达情况。结果：52例肺癌组织中bcl-2、bax蛋白表达阳性率分别为42.3％、59.61％。肺癌中bcl-2蛋白过表达在低分化癌、Ⅲ期肺癌中高于高分化癌以及Ⅰ期肺癌差异有显著性意义(P＜0.01)。p53mRNA、bax蛋白的阳性表达与bcl-2蛋白呈负相关。结论：bcl-2蛋白在晚期肺癌中过表达，p53mRNA、bax蛋白在早期肺癌中起着重要作用，它们共同参与细胞內死亡和存活信息的平衡状态的调节。" @default.
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- W3030817811 date "2002-11-28" @default.
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- W3030817811 title "The Expression of bcl-2,bax Protein and p53mRNA in Lung Cancer" @default.
- W3030817811 doi "https://doi.org/10.3760/cma.j.issn.1006-9801.2002.06.006" @default.
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