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• W3030825055 abstract "Abstract microRNAs (miRNAs) and circular RNAs (circRNAs) are important for endometrial receptivity establishment and embryo implantation in mammals. miR‐34a and miR‐34c are highly expressed in caprine receptive endometrium (RE). Herein, the functions and mechanisms of miR‐34a/c in caprine endometrial epithelial cell (CEEC) apoptosis and RE establishment were investigated. miR‐34a/c downregulated the expression level of centrosomal protein 55 ( CEP55 ) and were sponged by circRNA8073 (circ‐8073), thereby exhibiting a negative interaction in CEEC. miR‐34a/c induced CEEC apoptosis by targeting circ‐8073/CEP55 through the regulation of the RAS/RAF/MEK/ERK and phosphoitide 3‐kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways. Positive and negative feedback loops and cross‐talk were documented between the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways. miR‐34a/c regulated the levels of RE marker genes, including forkhead box M1, vascular endothelial growth factor, and osteopontin ( OPN ). These results suggest that miR‐34a/c not only induce CEEC apoptosis by binding to circ‐8073 and CEP55 via the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways, but may also regulate RE establishment in dairy goats." @default.
• W3030825055 created "2020-06-05" @default.
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• W3030825055 date "2020-05-31" @default.
• W3030825055 modified "2023-10-12" @default.
• W3030825055 title "miR‐34a/c induce caprine endometrial epithelial cell apoptosis by regulating circ‐8073/<i>CEP55</i> via the <i>RAS/RAF/MEK/ERK</i> and <i>PI3K/AKT/mTOR</i> pathways" @default.
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• W3030825055 doi "https://doi.org/10.1002/jcp.29821" @default.
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